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Titolo:
DISTURBED ENERGY-BALANCE IN SKELETAL-MUSCLE OF PATIENTS WITH UNTREATED PRIMARY HYPERTENSION
Autore:
RONQUIST G; SOUSSI B; FRITHZ G; SCHERSTEN T; WALDENSTROM A;
Indirizzi:
UNIV UPPSALA HOSP,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UMEA UNIV HOSP,DEPT INTERNAL MED UMEA SWEDEN CENT HOSP ESKILSTUNA,DEPT INTERNAL MED ESKILSTUNA SWEDEN GOTHENBURG UNIV,WALLENBERG LAB,BIOENERGET GRP GOTHENBURG SWEDEN
Titolo Testata:
Journal of internal medicine
fascicolo: 2, volume: 238, anno: 1995,
pagine: 167 - 174
SICI:
0954-6820(1995)238:2<167:DEISOP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED CHOLESTEROL CONTENT; NA+/H+ ANTIPORT ACTIVITY; ERYTHROCYTE-MEMBRANES; INTRACELLULAR PH; BLOOD-PRESSURE; CELL-MEMBRANES; CALCIUM; RAT; PERMEABILITY; RESISTANCE;
Keywords:
ENERGY CHARGE; INTRACELLULAR PH; MUSCLE BIOENERGETICS; NMR SPECTROSCOPY; PHOSPHOCREATINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G. Ronquist et al., "DISTURBED ENERGY-BALANCE IN SKELETAL-MUSCLE OF PATIENTS WITH UNTREATED PRIMARY HYPERTENSION", Journal of internal medicine, 238(2), 1995, pp. 167-174

Abstract

Objective. It has been shown that the distribution of Na+ and Ca2+ invarious cells is abnormal in patients with untreated primary hypertension, indicating an altered membrane permeability in these cells. Thiswould activate certain ion pumps and thereby enhance ATP turnover. Weinvestigated possible alterations in energy economy of skeletal muscle tissue. Design. Skeletal muscle energetics were studied in vitro andin vivo in patients with untreated primary hypertension. Phosphocreatine (PCr), energy charge (EC) and total adenylate values were assessed. Setting. The study was performed at the outpatient clinic of a general hospital and at a university clinical chemistry department and at aspecialized bioenergetic laboratory. Subjects. Altogether, 17 patients with untreated primary hypertension were examined together with matched, healthy and normotensive controls with normal body-mass index. Main outcome measures. Skeletal muscle biopsies were obtained from 10 patients and 10 controls for analysis of high energy phosphate compounds. Another seven patients were enrolled for in vivo NMR spectroscopy. Results. We found a decrease of 30% (P < 0.01) of PCr content in the patients, whilst EC and total adenylates were unchanged, Nuclear magnetic resonance spectroscopy showed an abnormal decrease of PCr during exercise followed by a markedly slower regeneration of PCr during post-exercise recovery parallelled by a slower recovery of pH. This phenomenon was mirrored by a more pronounced decrease of ATP/P-i in patients during exercise and a slower recovery of ATP/P-i.Conclusion. The data are compatible with an increased ATP turnover in skeletal muscle cells of patients with untreated primary hypertension although ATP was favoured and kept at a normal resting level at the expense of the PCr store.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:53:22