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Titolo:
PREVALENCE OF HYPERTROPHIC CARDIOMYOPATHY IN A GENERAL-POPULATION OF YOUNG-ADULTS - ECHOCARDIOGRAPHIC ANALYSIS OF 4111 SUBJECTS IN THE CARDIA STUDY
Autore:
MARON BJ; GARDIN JM; FLACK JM; GIDDING SS; KUROSAKI TT; BILD DE;
Indirizzi:
MINNEAPOLIS HEART INST FDN,DIV CARDIOVASC RES,920 E 28TH ST,STE 40 MINNEAPOLIS MN 55407 UNIV CALIF IRVINE,IRVINE MED CTR,DIV CARDIOL ORANGE CA 92668 UNIV CALIF IRVINE,IRVINE MED CTR,DIV EPIDEMIOL ORANGE CA 92668 UNIV MINNESOTA,SCH MED,DIV GEN & PREVENT MED MINNEAPOLIS MN 55455 NORTHWESTERN UNIV,SCH MED,DIV PEDIAT CARDIOL CHICAGO IL 00000 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892
Titolo Testata:
Circulation
fascicolo: 4, volume: 92, anno: 1995,
pagine: 785 - 789
SICI:
0009-7322(1995)92:4<785:POHCIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; TWO-DIMENSIONAL ECHOCARDIOGRAPHY; SYSTOLIC ANTERIOR MOTION; M-MODE ECHOCARDIOGRAPHY; SUDDEN-DEATH; CLINICAL MANIFESTATIONS; CARDIOVASCULAR-DISEASE; PATHO-PHYSIOLOGY; PATTERNS; PROGNOSIS;
Keywords:
CARDIOMYOPATHY; ECHOCARDIOGRAPHY; HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Maron et al., "PREVALENCE OF HYPERTROPHIC CARDIOMYOPATHY IN A GENERAL-POPULATION OF YOUNG-ADULTS - ECHOCARDIOGRAPHIC ANALYSIS OF 4111 SUBJECTS IN THE CARDIA STUDY", Circulation, 92(4), 1995, pp. 785-789

Abstract

Background Hypertrophic cardiomyopathy (HCM) is a genetically transmitted disease and an important cause of morbidity and sudden cardiac death in young people, including competitive athletes. At present, however, few data exist to estimate the prevalence of this disease in largepopulations. Methods and Results As part of the Coronary Artery Risk Development in (Young) Adults (CARDIA) Study, an epidemiological studyof coronary risk factors, 4111 men and women 23 to 35 years of age selected from the general population of four urban centers had technically satisfactory echocardiographic studies during 1987 through 1988. Probable or definite echocardiographic evidence of HCM was present in 7 subjects (0.17%) on the basis of identification of a hypertrophied, nondilated left ventricle and maximal wall thickness greater than or equal to 15 mm that were not associated with systemic hypertension. Prevalence in men and women was 0.26:0.09%; in blacks and whites, 0.24:0.10%. Ventricular septal thickness was 15 to 21 mm (mean, 17 mm) in the 7subjects. Only 1 of the 7 subjects had ever experienced important cardiac symptoms attributable to HCM, had previously been suspected of having cardiovascular disease, or had obstruction to left ventricular outflow; 4 other subjects had relatively mild systolic anterior motion of the mitral valve that was insufficient to produce dynamic basal outflow obstruction. ECGs were abnormal in 5 of the 7 subjects. Five otherstudy subjects had left ventricular wall thicknesses of 15 to 21 mm that were a consequence of systemic hypertension. Conclusions HCM was present in about 2 of 1000 young adults. These unique population-based data will aid in assessments of the impact of HCM-related mortality and morbidity in the general population and the practicality of screening large populations for HCM, including those comprising competitive athletes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:12:37