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Titolo:
SUBCLINICAL DISEASE AS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR-DISEASE
Autore:
KULLER LH; SHEMANSKI L; PSATY BM; BORHANI NO; GARDIN J; HAAN MN; OLEARY DH; SAVAGE PJ; TELL GS; TRACY R;
Indirizzi:
UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL,130 DESOTO ST PITTSBURGH PA 15261 UNIV WASHINGTON,SCH MED SEATTLE WA 00000 UNIV CALIF IRVINE,DIV CARDIOL DAVIS CA 00000 UNIV CALIF SACRAMENTO,DEPT INTERNAL MED SACRAMENTO CA 00000 GEISINGER MED CTR,DIV RADIOL DANVILLE PA 17822 NHLBI,DECA BETHESDA MD 00000 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV VERMONT,DEPT PATHOL BIOCHEM COLCHESTER VT 00000
Titolo Testata:
Circulation
fascicolo: 4, volume: 92, anno: 1995,
pagine: 720 - 726
SICI:
0009-7322(1995)92:4<720:SDAAIR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; UNRECOGNIZED MYOCARDIAL-INFARCTION; BLOOD-PRESSURE INDEX; ARTERIAL-DISEASE; FOLLOW-UP; MORTALITY; ATHEROSCLEROSIS; CHOLESTEROL; HEALTH; OLDER;
Keywords:
CARDIOVASCULAR DISEASES; MORBIDITY; MORTALITY; RISK FACTORS; AGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
L.H. Kuller et al., "SUBCLINICAL DISEASE AS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR-DISEASE", Circulation, 92(4), 1995, pp. 720-726

Abstract

Background The primary aim of the present study was to determine the relation between measures of subclinical cardiovascular disease and the incidence of clinical cardiovascular disease among 5201 adults 65 years of age or older who were participating in the Cardiovascular Health Study. Methods and Results A new method of classifying subclinical disease at baseline examination in the Cardiovascular Health Study included measures of ankle-brachial blood pressure, carotid artery stenosis and wall thickness, ECG and echocardiographic abnormalities, and positive response to the Rose Angina and Claudication Questionnaire. Participants were followed for an average of 2.39 years (maximum, 3 years). For participants without evidence of clinical cardiovascular diseaseat baseline, the presence of subclinical disease compared with no subclinical disease was associated with a significant increased risk of incident total coronary heart disease including CHD deaths and nonfatalMI and angina pectoris for both men and women. For individuals with subclinical disease, the increased risk of total coronary heart diseasewas 2.0 for men and 2.5 for women, and the increased risk of total mortality was 2.9 for men and 1.7 for women. The increased risk changed little after adjustment for other risk factors, including lipoprotein levels, blood pressure, smoking, and diabetes. Conclusions The measurement of subclinical disease provides an approach for identifying high-risk older individuals who may be candidates for more active intervention to prevent clinical disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 16:53:23