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Titolo:
GENETIC-DIFFERENCES OF LIPID-METABOLISM IN MACROPHAGES FROM C57BL 6J AND C3H/HEN MICE/
Autore:
ISHII I; ITO Y; MORISAKI N; SAITO Y; HIROSE S;
Indirizzi:
CHIBA UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM,INAGE KU,1-33 YAYOI CHO CHIBA 263 JAPAN CHIBA UNIV,SCH MED,DEPT INTERNAL MED 2 CHIBA 280 JAPAN YAMAGATA UNIV,DEPT LAB MED YAMAGATA 990 JAPAN
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 8, volume: 15, anno: 1995,
pagine: 1189 - 1194
SICI:
1079-5642(1995)15:8<1189:GOLIMF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL ESTERASE-ACTIVITY; INBRED STRAINS; ATHEROSCLEROTIC LESIONS; DENSITY-LIPOPROTEIN; SUSCEPTIBILITY; HYDROLYSIS; EXPRESSION; CELLS;
Keywords:
HIGH-CHOLESTEROL DIET; NEUTRAL CHOLESTEROL ESTERASE; C57BL/6J MOUSE; MACROPHAGE; ACYL COA-CHOLESTEROL ACYLTRANSFERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
I. Ishii et al., "GENETIC-DIFFERENCES OF LIPID-METABOLISM IN MACROPHAGES FROM C57BL 6J AND C3H/HEN MICE/", Arteriosclerosis, thrombosis, and vascular biology, 15(8), 1995, pp. 1189-1194

Abstract

Cholesterol metabolism in macrophages from atherosclerosis-prone C57BL/6J mice was compared with that in macrophages from atherosclerosis-resistant C3H/HeN mice. Plasma total cholesterol levels of both types of mice were significantly increased, but HDL cholesterol level was increased only in C3H/HeN mice when a high-cholesterol diet (1% cholesterol) was fed for 5 weeks. After incubation of macrophages from male andfemale mice on the high-cholesterol diet with beta-VLDL for 24 hours,cholesterol content in macrophages from C57BL/6J was approximately 1.5- to 2.0-fold higher than in those from C3H/HeN mice. [H-3]Cholesterol oleate-beta-VLDL incorporation into macrophages from C57BL/6J mice on the high-cholesterol diet was greater than incorporation into those from C3H/HeN mice. The release of [3H]cholesterol from macrophages from C57BL/6J mice on the high-cholesterol diet was one seventh that frommacrophages from C57BL/6J mice on the basal diet or that from macrophages from C3H/HeN mice on the basal or high-cholesterol diet. Acid cholesterol esterase activity was almost the same in macrophages from anygroup. Acyl CoA:cholesterol acyltrans ferase activity in macrophages from C57BL/6J mice on the high-cholesterol diet increased compared with that from macrophages from C57BL/6J mice on the normal diet. Neutralcholesterol esterase activity in macrophages from C57BL/6J mice was about half of that in macrophages from C3H/HeN mice independent of the type of diet. There were no sex differences in these metabolisms. Considered with our previous data, these results suggested that a high-cholesterol diet may cause metabolic changes to accumulate cholesterol ester in macrophages from C57BL/6J mice in accordance with genetic abnormalities.

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Documento generato il 28/11/20 alle ore 00:56:04