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Titolo:
A MODEL FOR ACUTE RESPIRATORY-FAILURE INDUCED BY TRACHEAL INSTILLATION OF HOMOLOGOUS PLASMA OR PROTEIN-RICH PULMONARY-EDEMA FLUID
Autore:
EIJKING EP; GOMMERS D; SO KL; DEMAAT MPM; LACHMANN B;
Indirizzi:
ERASMUS UNIV ROTTERDAM,DEPT ANESTHESIOL,ROOM EE 2393,POST BOX 1738 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT ANESTHESIOL 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT INTERNAL MED 2 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
ACP. Applied cardiopulmonary pathophysiology
fascicolo: 3, volume: 5, anno: 1995,
pagine: 129 - 134
SICI:
0920-5268(1995)5:3<129:AMFARI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACTANT REPLACEMENT THERAPY; BRONCHOALVEOLAR LAVAGE FLUID; DISTRESS SYNDROME; LUNG SURFACTANT; MEMBRANE;
Keywords:
ANIMAL MODEL; ACUTE RESPIRATORY FAILURE; BLOOD GASES; HIGH-PERMEABILITY EDEMA FLUID; PLASMA; PULMONARY SURFACTANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Eijking et al., "A MODEL FOR ACUTE RESPIRATORY-FAILURE INDUCED BY TRACHEAL INSTILLATION OF HOMOLOGOUS PLASMA OR PROTEIN-RICH PULMONARY-EDEMA FLUID", ACP. Applied cardiopulmonary pathophysiology, 5(3), 1995, pp. 129-134

Abstract

Both ARDS and established neonatal RDS are characterized by intraalveolar protein-rich oedema fluid, capable of inhibiting surfactant function. This study investigated the possibility to use homologous plasma or pulmonary oedema fluid to induce acute respiratory failure due to inhibition of pulmonary surfactant. The study demonstrated that both plasma and oedema fluid, intratracheally instilled in healthy rats, led to respiratory failure as evidenced by increase of PaCO2 and decrease of PaO2, and to increased minimal surface tension of bronchoalveolar lavage material due to interference with the surfactant layer. In contrast to rats receiving plasma, bronchoalveolar lavage fluid of rats receiving oedema fluid showed a high percentage of neutrophils, suggesting the presence of chemotactic factors in the oedema fluid. It is concluded that both plasma and oedema fluid have comparable inhibitory capacity on surfactant function. This model, which leads to an ARDS-like form of acute respiratory failure, may be useful for the evaluation of various aspects of inhibition of exogenous surfactant by high alveolarprotein concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:19:44