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Titolo:
THE NEUROKININ(1) RECEPTOR ANTAGONIST CP-99,994 REDUCES CATALEPSY PRODUCED BY THE DOPAMINE-D-2 RECEPTOR ANTAGONIST RACLOPRIDE - CORRELATIONWITH EXTRACELLULAR ACETYLCHOLINE LEVELS IN STRIATUM
Autore:
ANDERSON JJ; RANDALL S; CHASE TN;
Indirizzi:
NINCDS,EXPTL THERAPEUT BRANCH,BLDG 10,ROOM 5C215,10 CTR DR MSC 1406 BETHESDA MD 20892
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 2, volume: 274, anno: 1995,
pagine: 928 - 936
SICI:
0022-3565(1995)274:2<928:TNRACR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SUBSTANTIA NIGRA; FREELY MOVING RATS; CHOLINERGIC NEURONS; GENE-EXPRESSION; MESSENGER-RNA; PHENOTYPICAL CHARACTERIZATION; STRIATOPALLIDAL NEURONS; BASAL FOREBRAIN; BINDING-SITES; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Anderson et al., "THE NEUROKININ(1) RECEPTOR ANTAGONIST CP-99,994 REDUCES CATALEPSY PRODUCED BY THE DOPAMINE-D-2 RECEPTOR ANTAGONIST RACLOPRIDE - CORRELATIONWITH EXTRACELLULAR ACETYLCHOLINE LEVELS IN STRIATUM", The Journal of pharmacology and experimental therapeutics, 274(2), 1995, pp. 928-936

Abstract

The ability of the substance P (NK1) receptor antagonist CP-99,994 toalter catalepsy induced by a dopamine D-1 or D-2 receptor antagonist and the ability of CP-99,944 to influence acetylcholine (ACh) release in the striatum were investigated in rats. Catalepsy produced by the D-1 antagonist SCH 23390 (0.5 mg/kg s.c.) was not altered by CP-94,994 (0.5, 2.5, or 10 mg/kg s.c.). In contrast, catalepsy induced by the D-2 antagonist raclopride (2.5 mg/kg i.p.) was attenuated by CP-99,994 (2.5 and 10 mg/kg). CP-99,994 (10 mg/kg) did not stimulate locomotion when given alone. The less active enantiomer of CP-99,994, CP-I 00,263 (10 mg/kg) did not alter raclopride-induced catalepsy. Both systemic administration and intrastriatal perfusion of CP-99,994 alone decreasedstriatal ACh release. Bilateral intrastriatal perfusion of CP-99,994 (40 and 100 mu M) reduced catalepsy produced by raclopride and attenuated raclopride-induced increases in striatal ACh release. The reductions in the duration of catalepsy and decreases in striatal ACh release associated with CP-99,994 perfusion were positively correlated. These findings suggest that blockade of striatal NK1 receptors reduces catalepsy induced by a dopamine D-2 antagonist, an effect mediated, at least in part, by reducing striatal ACh release. Striatal NK1 receptors, therefore, may be a new therapeutic target for developing drugs that alleviate motor side effects associated with antipsychotic treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:53:13