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Titolo:
2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN)
Autore:
FUJITA T; HIROSE R; HAMAMICHI N; KITAO Y; SASAKI S; YONETA M; CHIBA K;
Indirizzi:
SETSUNAN UNIV,FAC PHARMACEUT SCI,45-1 NAGAOTOGE CHO HIRAKATA OSAKA 57301 JAPAN TAITO CO LTD,RES LAB,NAGATA KU KOBE HYOGO 653 JAPAN KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU KYOTO 60601 JAPAN YOSHITOMI PHARMACEUT IND LTD,RES LABS IRUMA SAITAMA 358 JAPAN
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 16, volume: 5, anno: 1995,
pagine: 1857 - 1860
SICI:
0960-894X(1995)5:16<1857:22-MES>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Fujita et al., "2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN)", Bioorganic & medicinal chemistry letters, 5(16), 1995, pp. 1857-1860

Abstract

2-Substituted 2-aminoethanol was shown to be the minimum essential structure for the immunosuppressive activity of ISP-I (myriocin, thermozymocidin) by simplification of 2-substituted 2-amino-1,3-propanediol, which was generated by modification of ISP-I. Among the series, 2-amino-4-(4-octylphenyl)butanol hydrochloride displayed comparably potent activity to 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride, FTY720.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:42:21