Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PATTERNS OF LYMPHOKINE PRODUCTION BY SEMLIKI-FOREST VIRUS-SPECIFIC T-CELL HYBRIDOMAS STIMULATED WITH DIFFERENT ANTIGEN-PRESENTING CELLS
Autore:
WATARI E; YOKOMURO K;
Indirizzi:
NIPPON MED COLL,DEPT IMMUNOL & MICROBIOL,BUNKYO KU,1-1-5 SENDAGI TOKYO 113 JAPAN
Titolo Testata:
Japanese Journal of Medical Science & Biology
fascicolo: 3, volume: 48, anno: 1995,
pagine: 131 - 143
SICI:
0021-5112(1995)48:3<131:POLPBS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MAST-CELLS; INFECTION; MICE; PROLIFERATION; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
E. Watari e K. Yokomuro, "PATTERNS OF LYMPHOKINE PRODUCTION BY SEMLIKI-FOREST VIRUS-SPECIFIC T-CELL HYBRIDOMAS STIMULATED WITH DIFFERENT ANTIGEN-PRESENTING CELLS", Japanese Journal of Medical Science & Biology, 48(3), 1995, pp. 131-143

Abstract

The development of infection seems to be influenced by the characteristics of antigen-presenting cells (APC) in the infection site. Thus, we compared the Semliki Forest virus (SFV)-antigen-presenting capacity of spleen cells, B-cell lymphomas, bone marrow-derived mast cells and nonparenchymal liver cells by measuring the production of lymphokines in SFV-specific T-cell hybridomas. Spleen cells were able to provide the signals needed to stimulate the production of IL-2, IL-4, IL-6 and IFN-gamma, while B lymphomas the signals leading to only IL-2 production. When bone marrow-derived mast cells were used as APC, SFV-specificT-cell hybridomas produced IL-2, IL-4 and IL-6 in the presence of soluble anti-CDS antibody. However, no lymphokine production was detectedwhen the SFV antigen was used instead of the antibody. Nonparenchymalliver cells containing liver endothelial cells and Kupffer cells havean APC function stimulating the production of IL-2 and IL-6. These findings confirmed that the T-cell hybridomas can be selectively stimulated by different APC to produce different lymphokines, and it would influence the development of the immune-mediated inflammatory response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:11:02