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Titolo:
STIMULATION OF NEUTROPOIESIS BY A SPECIAL STANDARDIZED MISTLETOE PREPARATION AFTER CYCLOPHOSPHAMIDE CHEMOTHERAPY IN MICE
Autore:
WEBER K; MENGS U; SCHWARZ T; BECKER H; LENTZEN H;
Indirizzi:
MADAUS AG,OSTMERHEIMER STR 198 D-51109 COLOGNE GERMANY MADAUS AG D-51109 COLOGNE GERMANY RCC RES & CONSULTING CO LTD ITINGEN SWITZERLAND
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 12, volume: 46, anno: 1996,
pagine: 1174 - 1178
SICI:
0004-4172(1996)46:12<1174:SONBAS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSIDE-SPECIFIC LECTIN; EXTRACT; ALPHA;
Keywords:
CYCLOPHOSPHAMIDE; IMMUNOSTIMULANT; LEKTINOL(R); MISTLETOE LECTIN; NEUTROPOIESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
K. Weber et al., "STIMULATION OF NEUTROPOIESIS BY A SPECIAL STANDARDIZED MISTLETOE PREPARATION AFTER CYCLOPHOSPHAMIDE CHEMOTHERAPY IN MICE", Arzneimittel-Forschung, 46(12), 1996, pp. 1174-1178

Abstract

Lektinol(R) is a special mistletoe preparation (SMP) with immunostimulatory activity, standardized with respect to bioactive mistletoe lectin, one of the most active components of mistletoe. In the present study, stimulation of leukopoiesis by SMP was investigated in mice after induction of myelosuppression by the cytostatic agent cyclophosphamide(CP). Under the experimental conditions described, CP induced severe leukopenia followed by a recovery phase where leukopoiesis was distinctly enhanced in mice treated additionally with SMP at daily intravenous doses in a range of 30 to 5000 mu l/kg body weight. This phenomenon was mainly due to a stimulation of granulopoiesis resulting in a stronger increase of metamyelocyte and mature neutrophil counts in the peripheral blood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:36:02