Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IGM CLASS AUTOANTIBODIES IN HUMAN CORD SERUM
Autore:
AILUS K; PALOSUO T;
Indirizzi:
NATL PUBL HLTH INST,DEPT IMMUNOBIOL,MANNERHEIMINTIE 166 SF-00300 HELSINKI FINLAND
Titolo Testata:
Journal of reproductive immunology
fascicolo: 1, volume: 29, anno: 1995,
pagine: 61 - 67
SICI:
0165-0378(1995)29:1<61:ICAIHC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUREUS COWAN-I; BLOOD B-CELLS; LYMPHOCYTES; INVITRO; AUTOREACTIVITY; POLYREACTIVITY; ANTIBODIES;
Keywords:
AUTOANTIBODIES; IMMUNOGLOBULIN IGM; HUMAN CORD BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K. Ailus e T. Palosuo, "IGM CLASS AUTOANTIBODIES IN HUMAN CORD SERUM", Journal of reproductive immunology, 29(1), 1995, pp. 61-67

Abstract

It has previously been shown that human neonatal B lymphocytes in vitro can synthesize autoantibodies which typically are of IgM class, polyreactive and of low affinity and thought to represent natural autoantibodies. We screened 1034 cord serum specimens to find sera with elevated IgM levels; 98 such sera were further examined by an enzyme-linkedimmunosorbent assay (ELISA) to determine whether antibodies against apanel of autoantigens could be found. We detected low levels of IgM class antibodies against cardiolipin, pyruvate dehydrogenase, single-stranded DNA, thyroglobulin and Fc fragments of IgG as rheumatoid factors. The IgM concentration correlated with autoantibody levels. The specificity of the autoantibody assays was confirmed by inhibition tests. We conclude that several types of autoantibodies can be found in some sera of newborns and that increased IgM concentration of some neonatesmay reflect a polyclonal antibody response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 19:14:17