Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PHARMACOLOGICAL CHARACTERIZATION OF GR82334, A TACHYKININ NK1 RECEPTOR ANTAGONIST, IN THE ISOLATED SPINAL-CORD OF THE NEONATAL RAT
Autore:
GUO JZ; YOSHIOKA K; ZHAO FY; HOSOKI R; MAEHARA T; YANAGISAWA M; HAGAN RM; OTSUKA M;
Indirizzi:
TOKYO MED & DENT UNIV,FAC MED,DEPT PHARMACOL TOKYO 113 JAPAN TOKYO MED & DENT UNIV,FAC MED,DEPT NEUROSURG TOKYO 113 JAPAN GLAXO GRP RES LTD,DEPT NEUROPHARMACOL WARE SG12 0DP HERTS ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 281, anno: 1995,
pagine: 49 - 54
SICI:
0014-2999(1995)281:1<49:PCOGAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P; NEWBORN RAT; RELEASE; REFLEX;
Keywords:
TACHYKININ RECEPTOR ANTAGONIST; GR82334; GR71251; L-659,877; SUBSTANCE P; NEUROKININ A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J.Z. Guo et al., "PHARMACOLOGICAL CHARACTERIZATION OF GR82334, A TACHYKININ NK1 RECEPTOR ANTAGONIST, IN THE ISOLATED SPINAL-CORD OF THE NEONATAL RAT", European journal of pharmacology, 281(1), 1995, pp. 49-54

Abstract

Pharmacological characteristics of ro-gamma-lactam]Leu(10),Trp(11)]physalaemin-(1-11) (GR82334), a tachykinin NK1 receptor antagonist, and its effects on slow depolarizing responses of lumbar ventral roots evoked by primary afferent stimulation were examined in isolated spinal cord preparations of neonatal rats. GR82334 (1-3 mu M) caused dose-dependent rightward shifts of the concentration-response curves for substance P, substance P methyl ester, delta-aminovaleryl [Pro(9),N-Me-Leu(10)]substance P-(7-11) (GR73632) and neurokinin A in normal artificial cerebrospinal fluid and those for substance P methyl ester, GR73632 and neurokinin A in the presence of tetrodotoxin. GR82334 (10 mu M) did not evoke gamma-aminobutyric acid (GABA) release from spinal cords of neonatal rats, whereas [D-Pro(9),[spiro-gamma-lactam] Leu(10),Trp(11)]substance P (GR71251), another tachykinin NK1 receptor antagonist, induced a significant increase in GABA release. GR82334 (1-3 mu M) markedly depressed the slow depolarizing response of ventral roots, referredto as slow ventral root potential, evoked by stimulation of the contralateral dorsal root or the ipsilateral saphenous nerve. In contrast, cyclo[Gln,Trp,Phe,Gly,Leu,Met] (L-659,877, 1 mu M), a selective tachykinin NK2 receptor antagonist, did not depress the saphenous nerve-evoked slow ventral root potential and did not antagonize the action of neurokinin A to induce ventral root depolarization. The present results provide further evidence for the involvement of substance P, neurokinin A and tachykinin NK1 receptors in the primary afferent-evoked slow ventral root potentials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 20:45:00