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Titolo:
THE EPIDEMIOLOGY OF DRUG-INDUCED AKATHISIA .1. ACUTE AKATHISIA
Autore:
SACHDEV P;
Indirizzi:
PRINCE HENRY HOSP,INST NEUROPSYCHIAT,POB 233 MATRAVILLE NSW 2036 AUSTRALIA UNIV NEW S WALES,SCH PSYCHIAT SYDNEY NSW AUSTRALIA PRINCE HENRY HOSP,INST NEUROPSYCHIAT SYDNEY NSW AUSTRALIA
Titolo Testata:
Schizophrenia bulletin
fascicolo: 3, volume: 21, anno: 1995,
pagine: 431 - 449
SICI:
0586-7614(1995)21:3<431:TEODA.>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; RECEIVING CANCER-CHEMOTHERAPY; AMOXAPINE-INDUCED AKATHISIA; INDUCED MOVEMENT-DISORDERS; TARDIVE-DYSKINESIA; SCHIZOPHRENIC-PATIENTS; CARBAMAZEPINE THERAPY; INDUCED PARKINSONISM; ANTIEMETIC EFFICACY; CLINICAL-TRIAL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
126
Recensione:
Indirizzi per estratti:
Citazione:
P. Sachdev, "THE EPIDEMIOLOGY OF DRUG-INDUCED AKATHISIA .1. ACUTE AKATHISIA", Schizophrenia bulletin, 21(3), 1995, pp. 431-449

Abstract

This article reviews the epidemiological data on drug-induced acute akathisia, examining studies in which akathisia was the primary focus as well as those in which it was one of a number of drug side effects studied. The studies are diverse in methodology and suffer from many limitations. Incidence rates for acute akathisia with conventional neuroleptics vary from 8 to 76 percent, with 20 to 30 percent being a conservative estimate; preliminary evidence suggests that the newer atypical antipsychotic drugs are less likely to produce acute akathisia. A number of nonneuroleptic drugs - in particular the serotonin-specific reuptake inhibitors - have been implicated in the development of akathisia, but the epidemiological data are limited. Risk factors for neuroleptic-induced akathisia are not completely understood. Drug dose, rate of increment of dose, and drug potency seem to be important, but the role of sociodemographic factors and other treatment-related variables is modest. Drug-induced parkinsonism is significantly correlated with akathisia. Evidence for iron deficiency as a risk factor is conflicting, and its contribution is likely to be minor.

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Documento generato il 28/01/20 alle ore 15:33:03