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Titolo:
A MORPHOLOGICAL ASSESSMENT OF BOVINE CHONDROCYTES CULTURED ON POLY(ETHYL METHACRYLATE) TETRAHYDROFURFURYL METHACRYLATE/
Autore:
SAWTELL RM; KAYSER MV; DOWNES S;
Indirizzi:
QUEENS MED CTR,SCH MED,DEPT HUMAN MORPHOL NOTTINGHAM NG7 2UH ENGLAND UCL,INST ORTHOPAED STANMORE HA7 4LP MIDDX ENGLAND
Titolo Testata:
Cells and materials
fascicolo: 1, volume: 5, anno: 1995,
pagine: 63 - 71
SICI:
1051-6794(1995)5:1<63:AMAOBC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTICULAR-CARTILAGE DEFECTS; HETEROCYCLIC METHACRYLATES; OSTEOCHONDRAL DEFECTS; CLINICAL-APPLICATIONS; RABBIT KNEE; PERICHONDRIAL GRAFT; PERIOSTEAL GRAFTS; REPAIR; SURFACES; IMPLANTS;
Keywords:
CARTILAGE REPAIR; CHONDROCYTES; IN VITRO; TISSUE CULTURE; BIOMATERIAL; SCANNING ELECTRON MICROSCOPY; POLY(ETHYL METHACRYLATE); TETRAHYDROFURFURYL METHACRYLATE; HYDROXYETHYL METHACRYLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Sawtell et al., "A MORPHOLOGICAL ASSESSMENT OF BOVINE CHONDROCYTES CULTURED ON POLY(ETHYL METHACRYLATE) TETRAHYDROFURFURYL METHACRYLATE/", Cells and materials, 5(1), 1995, pp. 63-71

Abstract

A heterocyclic methacrylate polymer system, PEMA/THFMA, has shown potential as a biomaterial for cartilage repair in a rabbit model and hasproperties making it suitable for use clinically. The ability of the polymer system, PEMA/THFMA, and a related system, PEMA/HEMA, to support chondrocytes in vitro was assessed by scanning electron microscopy. Chondrocytes adhered to the surface of the PEMA/THFMA by day one, having a rounded morphology and clustered appearance opposed to the Thermanox (R) control, where the cells had spread out and become fibroblastic in appearance. The chondrocytes divided rapidly on the PEMA/THFMA system by day three and had completely covered the surface by day seven. In contrast, chondrocytes did not adhere well to the more hydrophilicPEMA/HEMA system. A few cells were seen on the surface by day one andby days three and seven, there was no evidence of cell growth or spreading across the surface. In conclusion, the PEMA/THFMA system can support chondrocytes in vitro, whereas the PEMA/HEMA system does not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:04:21