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Titolo:
MECHANISMS OF ALTERED PROLACTIN SECRETION DUE TO THE ADMINISTRATION OF INTERLEUKIN-1-BETA INTO THE BRAIN VENTRICLES OF THE RAT
Autore:
RIVIER C;
Indirizzi:
SALK INST BIOL STUDIES,CLAYTON FDN LABS PEPTIDE BIOL,10010 N TORREY PINES RD LA JOLLA CA 92037
Titolo Testata:
Neuroendocrinology
fascicolo: 2, volume: 62, anno: 1995,
pagine: 198 - 206
SICI:
0028-3835(1995)62:2<198:MOAPSD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; CHRONIC INTRACEREBROVENTRICULAR INFUSION; PITUITARY-ADRENAL AXIS; MESSENGER-RNA; STIMULATE ADRENOCORTICOTROPIN; GROWTH-HORMONE; GONADAL AXIS; CYCLING RATS; ACTH RELEASE; STRESS;
Keywords:
INTERLEUKINS; PROLACTIN; DOPAMINE; ADRENAL STEROIDS; GONADAL STEROIDS; CORTICOTROPIN-RELEASING FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
C. Rivier, "MECHANISMS OF ALTERED PROLACTIN SECRETION DUE TO THE ADMINISTRATION OF INTERLEUKIN-1-BETA INTO THE BRAIN VENTRICLES OF THE RAT", Neuroendocrinology, 62(2), 1995, pp. 198-206

Abstract

The ability of the intracerebroventricular (icy) injection of interleukin-1 beta (IL-1 beta) to alter plasma prolactin (PRL) levels in ratsremains controversial, with reports of increases, decreases, or no changes in secretory rate. These discordant results may reflect, at least in part, the use of different doses of cytokines, as well as a gender specificity in the response of Gonadal steroids the brain circuits that control PRL release. In a first series of experiments, we investigated the The effect of one acute icy injection of IL-1 beta to alter PRL secretion in intact male and female rats. Using this paradigm, we also determined the potential modulating role of secretagogues reportedly released by IL-1 beta, such as dopamine, corticosterone and progesterone. A second series of experiments involved the long-term (3-5 days) icy infusion of IL-1 beta to identify the influence of gender on thepattern of PRL release. The acute icy injection of lL-1 beta (5-50 ng) to intact adult males or females caused comparable and significant (p < 0.01) decreases in plasma PRL levels 1-5.5 h after treatment. At the 8 h time point PRL secretion started to increase in females exposedto the cytokine, while PRL values of males were comparable in vehicle- and IL-1-injected rats. In intact males, blockade of pituitary dopamine receptors with domperidone (3.5 mg/kg) did not reverse the inhibitory effect of the immune protein. In either gender, blockade of IL-1-induced corticosterone and adrenal progesterone release with CRF antibodies was also without effect on PRL, secretion. We then studied the consequences of long-term IL-1 beta infusion (4 ng/h). Both intact malesand females showed significant decreases in PRL release measured between 11:00 and 14:00 h. In the evening (20:00-23:00 h), a marked sex difference became apparent with males still exhibiting decreased PRL levels, but females showing dramatically elevated PRL secretion. As previously reported [Rivier and Erickson, Endocrinology 1993;133:2431], these females also had markedly increased progesterone concentrations, a finding that suggested the possibility that the ovaries might participate in the gender-specific pattern of PRL secretion. This hypothesis was tested by comparing the effect of chronic IL-1 beta treatment in intact and ovariectomized (OVX) rats. On the third day of cytokine treatment, the expected decrease (mid-day) and increase (early evening) in PRL release were present in intact females infused with IL-1 beta. In contrast, OVX rats treated with the cytokine failed to exhibit significant changes in PRL levels at any time. Taken together, our results indicate that in both intact male and female rats, the acute decrease inPRL release caused by the icy injection of IL-1 beta is not secondaryto increases in circulating levels of corticosterone or progesterone,and also appears independent of dopamine influence. During long-term infusion with the cytokine, the dramatic increase in evening concentrations of PRL in females appears at least in part related to increased ovarian activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:45:55