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Titolo:
INDUCTION OF DIFFERENTIATION-REGULATED TRANSCRIPTION FACTOR OCT-6 SPECIFICALLY ACCOMPANIES MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I DOWN-REGULATION BY E1A OF ONCOGENIC ADENOVIRUS-TYPE-12
Autore:
PEEPER DS; SCHOUTEN GJ; TOEBES M; MEIJER D; ZWART R; VANDEWOUDE I; VANSCHAIK H; VANDEREB AJ; ZANTEMA A;
Indirizzi:
LEIDEN UNIV,SYLVIUS LAB,DEPT MOLEC CARCINOGENESIS,WASSERNAARSWEG 72 2333 AL LEIDEN NETHERLANDS LEIDEN UNIV,SYLVIUS LAB,DEPT MOLEC CARCINOGENESIS 2333 AL LEIDEN NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT CELL BIOL & GENET 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Cell growth & differentiation
fascicolo: 8, volume: 6, anno: 1995,
pagine: 977 - 984
SICI:
1044-9523(1995)6:8<977:IODTFO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMED RAT-CELLS; EMBRYONAL CARCINOMA-CELLS; OCTAMER BINDING-PROTEINS; NF-KAPPA-B; POU-DOMAIN; MESSENGER-RNAS; STEM-CELLS; 5 DNA; MOUSE EMBRYOGENESIS; C ADENOVIRUSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Peeper et al., "INDUCTION OF DIFFERENTIATION-REGULATED TRANSCRIPTION FACTOR OCT-6 SPECIFICALLY ACCOMPANIES MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I DOWN-REGULATION BY E1A OF ONCOGENIC ADENOVIRUS-TYPE-12", Cell growth & differentiation, 6(8), 1995, pp. 977-984

Abstract

The E1A genes from adenovirus (Ad) types 5 and 12 share the capacity to cooperate with a second oncogene to transform primary rodent cells in vitro. However, only Ad12-transformed cells are oncogenic in immunocompetent rodents, an event that requires conserved region 3 (CR3) of E1A to be intact. Ad12-induced tumorigenicity correlates with the E1A-CR3-dependent down-modulation of MHC class I transcription, contributing to escape from CTL-mediated immune surveillance. Expression of MHC class I antigens is also lacking in undifferentiated embryonal carcinoma cells. In these cells, MHC class I expression increases during differentiation in a process possibly involving octamer-binding proteins. We found that both nononcogenic and oncogenic Ad-transformed cells contained the ubiquitously expressed factor Oct-1. In contrast, only oncogenic Ad12-transformed cells that are derived from primary tell cultures expressed an additional octamer-binding factor, which we identifiedas Oct-6. The induction of Oct-6 expression was at the RNA level and was found to require an intact CR3 domain in Ad12 E1A. Like MHC class I expression, Oct-6 expression was not affected in already establishedcell lines expressing Ad12 EIA. The presence of Oct-6 in Ad12-transformed cells correlated with an increase in octamer-dependent transcription of a reporter gene, relative to Ad5-transformed cells. These results reveal a novel function for the Ad12-E1A oncoprotein and demonstrate an inverse correlation between the expression of Oct-6 and MHC classI genes in cells oncogenically transformed by Ad12.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:32:37