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Titolo:
AXES, BOUNDARIES AND COORDINATES - THE ABCS OF FLY LEG DEVELOPMENT
Autore:
HELD LI;
Indirizzi:
TEXAS TECH UNIV,DEPT BIOL SCI LUBBOCK TX 79409
Titolo Testata:
BioEssays
fascicolo: 8, volume: 17, anno: 1995,
pagine: 721 - 732
SICI:
0265-9247(1995)17:8<721:ABAC-T>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DROSOPHILA IMAGINAL DISKS; DORSAL-VENTRAL PATTERN; DECAPENTAPLEGIC GENE; WINGLESS PROTEIN; LIMB DEVELOPMENT; BETA HOMOLOG; EMBRYO; MELANOGASTER; COMPARTMENTS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
L.I. Held, "AXES, BOUNDARIES AND COORDINATES - THE ABCS OF FLY LEG DEVELOPMENT", BioEssays, 17(8), 1995, pp. 721-732

Abstract

Recent studies of gene expression in the developing fruitfly leg support a model - Meinhardt's Boundary Model - which seems to contradict the prevailing paradigm for pattern formation in the imaginal discs of Drosophila - the Polar Coordinate Model. Reasoning from geometric first principles, this article examines the strengths and weaknesses of these hypotheses, plus some baffling phenomena that neither model can comfortably explain. The deeper question at issue is: how does the fly'sgenome encode the three-dimensional anatomy of the adult? Does it demarcate territories and boundaries (as in a geopolitical map) and then use those boundaries and their points of intersection as a scaffoldingon which to erect the anatomy (the Boundary Model)? Or does it assigncellular fates within a relatively seamless coordinate system (the Polar Coordinate Model)? The existence of hybrid Cartesian-polar models shows that the alternatives may not be so clear-cut: a single organ might utilize different systems that are spatially superimposed or temporally sequential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:22:50