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Titolo:
ANIMAL-MODELS OF POLYCYSTIC KIDNEY-DISEASE
Autore:
AZIZ N;
Indirizzi:
HARVARD UNIV,CHILDRENS HOSP,SCH MED,DEPT PEDIAT,DIV NEPHROL,300 LONGWOOD AVE BOSTON MA 02115
Titolo Testata:
BioEssays
fascicolo: 8, volume: 17, anno: 1995,
pagine: 703 - 712
SICI:
0265-9247(1995)17:8<703:AOPK>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL CYSTIC-DISEASE; MURINE MODEL; MOUSE KIDNEY; CPK MOUSE; C-MYC; NORDIHYDROGUAIARETIC ACID; PROTOONCOGENE EXPRESSION; MEMBRANE PROTEIN; GENE; MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
N. Aziz, "ANIMAL-MODELS OF POLYCYSTIC KIDNEY-DISEASE", BioEssays, 17(8), 1995, pp. 703-712

Abstract

Polycystic kidney disease (PKD) is one of the most prevalent causes of heritable renal failure. The disease is characterized by the occurrence of numerous fluid-filled cysts within the parenchyma of kidney. The cysts are epithelial in origin and expand in size, leading to crowding of normal kidney tissue. Ultimately, there is gross enlargement of the kidneys with loss of normal functions, and death usually occurs because of complications related to renal failure. Animal models of polycystic kidney disease are proving to be extremely useful for studying the molecular basis of renal cyst formation and for the isolation of genes carrying the mutations. This article describes the various animalmodels of polycystic kidney disease, spontaneously and experimentallyderived, that have recently been identified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:50:31