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Titolo:
INVESTIGATION ON A NEW MODIFIED USP XANTHAN WITH TABLET-DISINTEGRATING PROPERTIES
Autore:
RIZK S; BARTHELEMY C; DURU C; GUYOTHERMANN AM;
Indirizzi:
FAC SCI PHARMACEUT & BIOL,PHARM GALEN & BIOPHARM LAB LILLE FRANCE FAC SCI PHARMACEUT & BIOL,PHARM GALEN & BIOPHARM LAB LILLE FRANCE FAC PHARM MONTPELLIER,LAB PHARM GALEN & BIOPHARM & PHARMACOTECH F-34060 MONTPELLIER FRANCE
Titolo Testata:
Drug development and industrial pharmacy
fascicolo: 1, volume: 23, anno: 1997,
pagine: 19 - 26
SICI:
0363-9045(1997)23:1<19:IOANMU>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
S. Rizk et al., "INVESTIGATION ON A NEW MODIFIED USP XANTHAN WITH TABLET-DISINTEGRATING PROPERTIES", Drug development and industrial pharmacy, 23(1), 1997, pp. 19-26

Abstract

The disintegrating efficiency of a new USP xanthan derivative, Xanthan SM(R), was evaluated. First, the physical parameters of Xanthan SM were compared to USP xanthan, a highly gelifying excipient, and AcDiSol(R), a powerful and well-known disintegrant. Tablets were prepared by direct compression using acetylsalicylic acid as the drug. The effective amount of each disintegrant was determined. The influence on compression behavior, disintegration time, and drug dissolution rate was considered. This study makes it clear that the characteristics of XanthanSM are totally different from those of USP xanthan. Xanthan SM provedto be as good as AcDiSol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:22:58