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Titolo:
SPECT IMAGING OF ISCHEMIC MYOCARDIUM USING A TECHNETIUM-99M-NITROIMIDAZOLE LIGAND
Autore:
RUMSEY WL; KUCZYNSKI B; PATEL B; BAUER A; NARRA RK; EATON SM; NUNN AD; STRAUSS HW;
Indirizzi:
ZENECA PHARMACEUT,DEPT PHARMACOL,PHD-B239 WILMINGTON DE 19897 BRISTOL MYERS SQUIBB PHARMACEUT RES INST PRINCETON NJ 08543
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 8, volume: 36, anno: 1995,
pagine: 1445 - 1450
SICI:
0161-5505(1995)36:8<1445:SIOIMU>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT CAROTID-BODY; OXYGEN DEPENDENCE; MECHANISM; REDUCTION; TISSUE;
Keywords:
SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY; MYOCARDIAL ISCHEMIA; TECHNETIUM-99M-NITROIMIDAZOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
W.L. Rumsey et al., "SPECT IMAGING OF ISCHEMIC MYOCARDIUM USING A TECHNETIUM-99M-NITROIMIDAZOLE LIGAND", The Journal of nuclear medicine, 36(8), 1995, pp. 1445-1450

Abstract

This investigation evaluates the efficacy of a Tc-99m-labeled nitroimidazole (BMS-181321) in identifying oxygen-deprived tissue in two canine models of myocardial ischemia. Methods: For both models (A and B), epicardial microvascular oxygen pressure (mPO(2)) was monitored by measuring the oxygen-dependent quenching of phosphorescence lifetime of Palladium mesotetra (4-carboxyphenyl) porphine. In Model A (beagles, n = 5), BMS-181321 was administered intravenously and a distal branch ofthe left anterior descending coronary artery (LAD) was ligated completely 40 sec later. Ten minutes later, the ligature was released establishing tissue reoxygenation. In Model B, flow through the LAD was reduced until the mPO(2) was about 2 Torr. After bolus administration of BMS-181321 (50-60 mCi), coronary ischemia was continued for a residenceperiod of up to 4 hr. Results: With Model A, SPECT reconstructions revealed a small ischemic area in three of five dogs, however, a transmural accumulation of the compound was evident in the autoradiograms from all dogs. In the two animals in which the defect was not observed bySPECT, the ischemic episode had nominal effects on the ratio of +/-dp/dt (<4% change as compared to baseline values). In Model B, SPECT reconstructions showed positive images of the oxygen-deprived area withinthe mid- to apical regions of the left ventricle (n = 5). Autoradiographic analysis showed a transmural association with cells resulting inan ischemic-to-nonischemic ratio of 3.5 +/- 0.4 (n = 4) for animals with similar residence times. Conclusion: The results from both models suggest that BMS-181321 provides a noninvasive marker of regional ischemia in the heart and that this compound may have clinical utility fordetection of coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 22:08:58