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Titolo:
APPLICATION OF PERCOLATION THEORY TO CHARACTERIZE THE RELEASE BEHAVIOR OF CARTEOLOL MATRIX SYSTEMS
Autore:
CARABALLO I; HOLGADO MA; FERNANDEZAREVALO M; MILLAN M; RABASCO AM;
Indirizzi:
UNIV SEVILLE,FAC PHARM,DEPT PHARMACEUT TECHNOL E-41012 SEVILLE SPAIN
Titolo Testata:
Drug development and industrial pharmacy
fascicolo: 1, volume: 23, anno: 1997,
pagine: 1 - 8
SICI:
0363-9045(1997)23:1<1:AOPTTC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TABLETS; HYDROCHLORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
I. Caraballo et al., "APPLICATION OF PERCOLATION THEORY TO CHARACTERIZE THE RELEASE BEHAVIOR OF CARTEOLOL MATRIX SYSTEMS", Drug development and industrial pharmacy, 23(1), 1997, pp. 1-8

Abstract

The paper reports a study of the capability of the percolation theoryto explain the influence of several formulation factors over the release behavior of carteolol hydrochloride inert matrix systems. For thispurpose, previously prepared matrix systems have been employed. The characterization of these matrices by means of ''classical theories'' has been reported in previous papers. Similar percolation thresholds have been found (52.7%, 56.2 % v/v for the insoluble phase and 48.2% to 51.2% v/v for the soluble phase), even with changing formulation factors such as nature and percentage of polymer, type of wetting liquid and nature, and percentage of filler. This fact suggests an advantage far the application of percolation theory to the rationalization of pharmaceutical dosage forms design. From the obtained results, the characterization of a multicomponent system on the basis of percolation theory seems to be rather general. On the other hand, the relatively high percolation thresholds obtained can be attributed to the different particle sizes of the components according to correlated percolation models.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 02:37:36