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Titolo:
DERIVATIVES OF COLCHICINE PREFERENTIALLY TAKEN UP BY THE LIVER - AN APPROACH TO THE TREATMENT OF LIVER FIBROSIS
Autore:
PALMERINI CA; FLORIDI A; ARIENTI G;
Indirizzi:
UNIV PERUGIA,DIPARTIMENTO BIOL CELLULAR & MOLEC,VIA GIOCHETTO I-06100PERUGIA ITALY UNIV PERUGIA,IST BIOCHIM & CHIM MED I-06100 PERUGIA ITALY
Titolo Testata:
Biotechnology and applied biochemistry
, volume: 22, anno: 1995,
parte:, 1
pagine: 15 - 22
SICI:
0885-4513(1995)22:<15:DOCPTU>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRRHOSIS; COLLAGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Palmerini et al., "DERIVATIVES OF COLCHICINE PREFERENTIALLY TAKEN UP BY THE LIVER - AN APPROACH TO THE TREATMENT OF LIVER FIBROSIS", Biotechnology and applied biochemistry, 22, 1995, pp. 15-22

Abstract

The distribution in the mouse of colchicine and of two colchicine derivatives, namely formylcolchicine/formylated serum albumin (FC/FTSA) and formylcolchicine/lactosaminated serum albumin (FC/LASA), was studied. The presence of radioactivity after the intravenous injection of labelled colchicine or of its derivatives was determined in liver, smallintestine, kidney and blood. The radioactivity of the derivatives wasbetter retained than that of colchicine. The derivatives accumulated in the liver to a much greater extent than colchicine, but were scarcely present in the gut. Tropism towards the liver might be important for the use of FC/LASA and FC/FTSA to control liver fibrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:17:45