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Titolo:
INHIBITION OF CATECHOLAMINE SYNTHESIS WITH ALPHA-METHYL-P-TYROSINE APPARENTLY INCREASES BRAIN SEROTONINERGIC ACTIVITY IN THE RAT - NO INFLUENCE OF PREVIOUS CHRONIC IMMOBILIZATION STRESS
Autore:
POL O; CAMPMANY L; ARMARIO A;
Indirizzi:
UNIV AUTONOMA BARCELONA,FAC CIENCIAS,DEPT BIOL CELULAR & FISIOL E-08193 BARCELONA SPAIN UNIV AUTONOMA BARCELONA,FAC CIENCIAS,DEPT BIOL CELULAR & FISIOL E-08193 BARCELONA SPAIN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 52, anno: 1995,
pagine: 107 - 112
SICI:
0091-3057(1995)52:1<107:IOCSWA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; LOCUS COERULEUS; HYDROXYLASE ACTIVITY; NORADRENALINE TURNOVER; NORADRENERGIC NEURONS; SEROTONERGIC NEURONS; )H-3>5-HYDROXYTRYPTAMINE RELEASE; 5-HYDROXYINDOLEACETIC ACID; HIPPOCAMPAL NORADRENALINE; TRYPTOPHAN-HYDROXYLASE;
Keywords:
CHRONIC STRESS; NORADRENERGIC SYSTEM; SEROTONINERGIC SYSTEM; IMMOBILIZATION; ALPHA-METHYL-P-TYROSINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
O. Pol et al., "INHIBITION OF CATECHOLAMINE SYNTHESIS WITH ALPHA-METHYL-P-TYROSINE APPARENTLY INCREASES BRAIN SEROTONINERGIC ACTIVITY IN THE RAT - NO INFLUENCE OF PREVIOUS CHRONIC IMMOBILIZATION STRESS", Pharmacology, biochemistry and behavior, 52(1), 1995, pp. 107-112

Abstract

The functional relationship between brain catecholamines and serotoninergic function was studied in stress-naive and chronically immobilized rats after blockade of catecholamine synthesis with alpha-methyl-p-tyrosine (alpha MpT). The levels of noradrenaline (NA), serotonin, and 5-hydroxyindole acetic acid (5-HIAA) in pens plus medulla, brainstem, hypothalamus, hippocampus, and frontal cortex, and those of 3-methoxy,4-hydroxypheniletileneglicol sulphate (MHPG-SO4) in the hypothalamus were measured by HPLC. Chronic immobilization (IMO) resulted in higherNA levels in pens plus medulla and hypothalamus, the latter area (theonly one in which the NA metabolite was determined) also showing slightly elevated MHPG-SO4 levels as compared to stress-naive rats. Chronic IMO did not alter either serotonin or 5-HIAA levels, but acute stress consistently increased 5-HIAA levels in all areas, independently of previous chronic stress. Administration of alpha-MpT drastically reduced NA and increased 5-HIAA levels in all brain regions excepting the frontal cortex. The effect of the drug on serotoninergic function was not altered by previous chronic exposure to IMO. These data suggest that the noradrenergic system appears to exert a tonic inhibitory effect on serotoninergic activity in the brain, with the intensity of the effect depending on the brain area studied. In addition, chronic stress does not appear to alter the functional relationship between noradrenergic and serotoninergic activities, although interactions might exist in more restricted brain areas; this deserves further study.

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Documento generato il 15/01/21 alle ore 23:14:37