Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIFFERENTIAL-EFFECTS OF CGS 12066B AND CP-94,253 ON MURINE SOCIAL ANDAGONISTIC BEHAVIOR
Autore:
BELL R; DONALDSON C; GRACEY D;
Indirizzi:
QUEENS UNIV BELFAST,SCH PSYCHOL BELFAST BT7 1NN ANTRIM NORTH IRELAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 52, anno: 1995,
pagine: 7 - 16
SICI:
0091-3057(1995)52:1<7:DOC1AC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR SUBTYPES; 5-HT1B AGONIST; MICE; DRUGS; ANTAGONISTS; AGGRESSION; LIGANDS; POTENT; MODELS; TFMPP;
Keywords:
CGS12066B; CP-94,253; 5-HT1B AGONISTS; SOCIAL BEHAVIOR; AGONISTIC BEHAVIOR; ANXIETY; ETHOLOGICAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R. Bell et al., "DIFFERENTIAL-EFFECTS OF CGS 12066B AND CP-94,253 ON MURINE SOCIAL ANDAGONISTIC BEHAVIOR", Pharmacology, biochemistry and behavior, 52(1), 1995, pp. 7-16

Abstract

Although it has been previously proposed that 5-HT1B agonism specifically attenuates rodent agonistic behaviour, more recent investigationshave indicated that such influences may be ancillary to an anxiogeniceffect. The present study examined the influences of two 5-HT1B agonists, CGS 12066B and CP-94,253, on murine agonistic behaviour. In a resident-intruder paradigm, CGS 12066B (0.5-5.0 mg/kg) decreased residentoffensive aggression, social interest, and exploration while dose-dependently enhancing defensive behaviours across the dose range tested. CP-94,253 (2.5-10.0 mg/kg) also reduced elements of resident offensivebehaviour whereas defensive behaviours were largely unchanged. Some elements of resident nonsocial and social behaviour were enhanced at 2.5 and 5.0 mg/kg but decreased at 10.0 mg/kg. The behavioural profile of CP-94,253, but not CGS 12066B, supports the proposal that 5-HT1B receptors inhibit agonistic behaviour without concomitant sedative or anxiogenic effects. Findings are discussed in relation to 5-HT1A/1B/2C receptors involved in agonistic behaviour and anxiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:05:43