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Titolo:
ROLE OF VITAMIN-K IN BONE METABOLISM
Autore:
VERMEER C; JIE KSG; KNAPEN MHJ;
Indirizzi:
UNIV LIMBURG,DEPT BIOCHEM,POB 616 6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
Annual review of nutrition
, volume: 15, anno: 1995,
pagine: 1 - 22
SICI:
0199-9885(1995)15:<1:ROVIBM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX GLA-PROTEIN; GAMMA-CARBOXYGLUTAMIC ACID; URINARY CALCIUM EXCRETION; CIRCULATING OSTEOCALCIN; DEPENDENT CARBOXYLASE; BLOOD-COAGULATION; ATHEROSCLEROTIC PLAQUES; ANTICOAGULANT-THERAPY; ORAL ANTICOAGULANTS; MINERAL CONTENT;
Keywords:
PHYLLOQUINONE; MENAQUINONE; OSTEOCALCIN; CALCIUM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
103
Recensione:
Indirizzi per estratti:
Citazione:
C. Vermeer et al., "ROLE OF VITAMIN-K IN BONE METABOLISM", Annual review of nutrition, 15, 1995, pp. 1-22

Abstract

Vitamin K is a cofactor required for the formation of gamma-carboxyglutamate (Gla) residues in proteins. Osteoblasts produce at least threedifferent Gla-containing proteins: osteocalcin, matrix Gla-protein, and protein S. After cellular secretion of these proteins, the main part of each remains bound to the hydroxyapatite matrix in bone, but their function remains unclear. Part of the newly synthesized osteocalcin is also set free into the bloodstream, where it may be used as a diagnostic marker for bone formation. Several studies have demonstrated that a poor vitamin K status is associated with an increased risk of osteoporotic bone fractures. Whether vitamin K supplementation will reducethe rate of bone loss in postmenopausal women remains a matter of debate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:42:57