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Titolo:
CARBOXY-TERMINAL PROPEPTIDE OF HUMAN TYPE-I COLLAGEN AND PYRIDINIUM CROSS-LINKS AS MARKERS OF BONE-GROWTH IN INFANTS 1 TO 18 MONTHS OF AGE
Autore:
LIEUWAFA M; SIERRA RI; SPECKER BL;
Indirizzi:
CHILDRENS HOSP,MED CTR,DEPT PEDIAT,DIV NEONATOL,231 BETHESDA AVE ML 541 CINCINNATI OH 45267 CHILDRENS HOSP,MED CTR,DEPT PEDIAT,DIV NEONATOL CINCINNATI OH 45267 UNIV CINCINNATI MED CINCINNATI OH 45267
Titolo Testata:
Journal of bone and mineral research
fascicolo: 6, volume: 10, anno: 1995,
pagine: 849 - 853
SICI:
0884-0431(1995)10:6<849:CPOHTC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
III PROCOLLAGEN PROPEPTIDES; SERUM CONCENTRATIONS; CHILDREN; RESORPTION; HORMONE; RADIOIMMUNOASSAY; DISEASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M. Lieuwafa et al., "CARBOXY-TERMINAL PROPEPTIDE OF HUMAN TYPE-I COLLAGEN AND PYRIDINIUM CROSS-LINKS AS MARKERS OF BONE-GROWTH IN INFANTS 1 TO 18 MONTHS OF AGE", Journal of bone and mineral research, 10(6), 1995, pp. 849-853

Abstract

Serum carboxy-terminal propeptide of human type I collagen (PICP) concentrations, as a marker for bone formation, and urinary pyridiniun (Pyd) cross-link concentrations, as a marker of bone resorption, were determined in 66 healthy infants aged 1-18 months who are being studied longitudinally. We hypothesized that there would be a positive correlation of growth velocity, increase in bone area, and bone mass accretion rates with PICP and Pyd cross-link concentrations. Since osteocalcinis currently used as a marker of bone formation, serum osteocalcin concentrations were also measured. Mean serum PICP and urinary Pyd cross-link concentrations were significantly greater than adult concentrations. Future growth velocity, increase in bone area, and bone mass accretion rates were not associated with PICP, Pyd cross-link, or osteocalcin concentrations. Growth velocity during the 3 months preceding sample collection correlated with serum PICP, Pyd/kg, and osteocalcin concentrations (r = 0.474, p < 0.001; r = 0.379, p < 0.001; and r = 0.516,p < 0.001, respectively). Previous increase in bone area correlated with serum PICP concentrations (r = 0.359, p = 0.01). The relationship between the infant's previous bone mass accretion rate and PICP was ofborderline significance (r = 0.281, p = 0.055). In summary, normativedata for PICP, Pyd cross-link concentrations, and parameters of bone growth are provided for infants 1-18 months of age and indicate that these markers reflect past and current bone metabolism and may be helpful in monitoring bone disorders in infants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:48:39