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Titolo:
CELLULAR-DISTRIBUTION OF THE MESSENGER-RNA FOR THE KAPPA-OPIOID RECEPTOR IN THE HUMAN NEOCORTEX - A NONISOTOPIC IN-SITU HYBRIDIZATION STUDY
Autore:
WEVERS A; SCHMIDT P; CSERPAN E; CSERPAN I; MADERSPACH K; STAAK M; SCHRODER H;
Indirizzi:
UNIV COLOGNE,DEPT ANAT 2,JOSEPH STELZMANN STR 9 D-50931 COLOGNE GERMANY UNIV COLOGNE,INST FORENS MED D-50931 COLOGNE GERMANY HUNGARIAN ACAD SCI,BIOL RES CTR,INST BIOCHEM H-6701 SZEGED HUNGARY HUNGARIAN ACAD SCI,BIOL RES CTR,INST GENET H-6701 SZEGED HUNGARY
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 195, anno: 1995,
pagine: 125 - 128
SICI:
0304-3940(1995)195:2<125:COTMFT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOLOGICAL CHARACTERIZATION; CEREBRAL-CORTEX; HUMAN FOREBRAIN; BINDING SITES; CLONING; BRAIN; ANATOMY; CDNA;
Keywords:
HUMAN CEREBRAL CORTEX; KAPPA OPIOID RECEPTOR; IN SITU HYBRIDIZATION; DIGOXIGENIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A. Wevers et al., "CELLULAR-DISTRIBUTION OF THE MESSENGER-RNA FOR THE KAPPA-OPIOID RECEPTOR IN THE HUMAN NEOCORTEX - A NONISOTOPIC IN-SITU HYBRIDIZATION STUDY", Neuroscience letters, 195(2), 1995, pp. 125-128

Abstract

Opioid receptors (OR) provide primary interaction sites of the human brain with opiates. Presently kappa-OR mRNA expression was studied in different cortical areas (A4, A10, A17) by in situ hybridization usingdigoxigenin-labeled oligonucleotides and an alkaline phosphatase-mediated color reaction. kappa-OR mRNA was expressed mainly in layers II/III and V pyramidal and layer VI multiform neurons. A4 giant pyramidal and A17 giant stellate neurons stood out labeled. These findings fit in with our data on kappa-OR protein distribution. Combined cellular assessment of protein and mRNA will enable the study kappa-OR expressionunder physiological and pathological conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:05:10