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Titolo:
RAT SKELETAL-MUSCLE METABOLISM IN EXPERIMENTAL HEART-FAILURE - EFFECTS OF PHYSICAL-TRAINING
Autore:
BRUNOTTE F; THOMPSON CH; ADAMOPOULOS S; COATS A; UNITT J; LINDSAY D; KAKLAMANIS L; RADDA GK; RAJAGOPALAN B;
Indirizzi:
OXFORD RADCLIFFE TRUST,MRC,BIOCHEM & CLIN MAGNET RESONANCE UNIT OXFORD OX3 9DU ENGLAND OXFORD RADCLIFFE TRUST,MRC,BIOCHEM & CLIN MAGNET RESONANCE UNIT OXFORD OX3 9DU ENGLAND OXFORD RADCLIFFE TRUST,DEPT CARDIOVASC MED OXFORD OX3 9DU ENGLAND OXFORD RADCLIFFE TRUST,DEPT PATHOL OXFORD OX3 9DU ENGLAND NATL HEART & LUNG INST,DEPT CARDIAC MED LONDON SW3 6LY ENGLAND
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 4, volume: 154, anno: 1995,
pagine: 439 - 447
SICI:
0001-6772(1995)154:4<439:RSMIEH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERIAL INSUFFICIENCY; REGIONAL BLOOD-FLOW; MYOCARDIAL-INFARCTION; MAGNETIC-RESONANCE; EXERCISE INTOLERANCE; ABNORMALITIES; HEMODYNAMICS; ADAPTATIONS; DYSFUNCTION; FATIGUE;
Keywords:
HEART FAILURE; P-31 MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL TRAINING; RAT; SKELETAL MUSCLE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
F. Brunotte et al., "RAT SKELETAL-MUSCLE METABOLISM IN EXPERIMENTAL HEART-FAILURE - EFFECTS OF PHYSICAL-TRAINING", Acta Physiologica Scandinavica, 154(4), 1995, pp. 439-447

Abstract

Skeletal muscle metabolic abnormalities exist in chronic heart failure. The influence of physical training on muscle metabolism after myocardial infarction was studied in a rat model. P-31 magnetic resonance spectroscopy and enzyme assays were performed in Wistar rats 12 weeks after coronary artery ligation. Infarcted rats were allocated randomly to either 6 weeks of training or non-training. Spectra were collected from the calf muscles during sciatic nerve stimulation at 2 Hz. Fibre typing and enzymatic assays were performed on the muscles of the contralateral non stimulated leg. Post-mortem rats were also divided into severe and moderate heart failure according to the lung weight per bodyweight. At 200 g twitch tension, phosphocreatine and pH were found tobe significantly lower in the non-trained severe heart failure group compared with the other groups. Phosphocreatine recovery half-time wassignificantly longer in the non-trained group with severe heart failure and correlated with the citrate synthase activity in the muscle. The training did not induce a change in the enzyme activities in the infarcted animals with moderate heart failure but did correct the lower citrate synthase activity in the non-trained severe heart failure animals. This normalization of muscle metabolism was achieved by training without any change in calf muscle mass, making atrophy unlikely to be the sole cause of the metabolic changes in heart failure. Training in rats with severe heart failure can reverse the abnormalities of skeletal muscle metabolism, implicating decreased physical activity in the aetiology of these changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:08:09