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Titolo:
SENSITIVITY OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR LEUKOCYTES TO VISIBLE-LIGHT
Autore:
FINOCCHIARO LME; POLACK E; NAHMOD VE; GLIKIN GC;
Indirizzi:
UNIV BUENOS AIRES,INST INVEST MED,SUSTANCIAS VASOACTIVAS LAB,DONATO ALVAREZ 3150 RA-1427 BUENOS AIRES DF ARGENTINA UNIV BUENOS AIRES,CONSEJO NACL INVEST CIENT & TECN,INST INVEST INGN GENET & BIOL MOLEC RA-1428 BUENOS AIRES DF ARGENTINA UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT RA-1428 BUENOS AIRES DF ARGENTINA
Titolo Testata:
Life sciences
fascicolo: 11, volume: 57, anno: 1995,
pagine: 1097 - 1110
SICI:
0024-3205(1995)57:11<1097:SOHPML>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; MELATONIN BIOSYNTHESIS; INTERFERON-GAMMA; PINEAL GLANDS; CELLS; PHOTORECEPTORS; VERTEBRATES; METABOLISM; SEROTONIN; RHYTHM;
Keywords:
PERIPHERAL BLOOD MONONUCLEAR LEUKOCYTES; SEROTONIN; MELATONIN; VISIBLE LIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
L.M.E. Finocchiaro et al., "SENSITIVITY OF HUMAN PERIPHERAL-BLOOD MONONUCLEAR LEUKOCYTES TO VISIBLE-LIGHT", Life sciences, 57(11), 1995, pp. 1097-1110

Abstract

Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [H-3]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10(-9) to 10(-5) M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10(-9) to 10(-7) M) stimulated [H-3]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 13:11:23