Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PANCREATIC-DUODENAL HOMEOBOX-1-ROLE IN GASTRIC ENDOCRINE PATTERNING
Autore:
LARSSON LI; MADSEN OD; SERUP P; JONSSON J; EDLUND H;
Indirizzi:
STATENS SERUM INST,DEPT MOL CELL BIOL,ARTILLERIVEJ 5,BLDG 81 DK-2300 COPENHAGEN S DENMARK HAGEDORN RES INST GENTOFTE DENMARK UMEA UNIV,DEPT MICROBIOL S-90187 UMEA SWEDEN
Titolo Testata:
Mechanisms of development
fascicolo: 2, volume: 60, anno: 1996,
pagine: 175 - 184
SICI:
0925-4773(1996)60:2<175:PHIGEP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-TRANSCRIPTION FACTOR; PERFUSED RAT STOMACH; INSULIN GENE; HOMEODOMAIN PROTEIN; ISLET CELLS; MESSENGER-RNA; SOMATOSTATIN EXPRESSION; INSITU HYBRIDIZATION; MOLECULAR-CLONING; TRANSGENIC MICE;
Keywords:
PDX1; IPF1; GASTRIN; SOMATOSTATIN; GENE KNOCK OUT; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
L.I. Larsson et al., "PANCREATIC-DUODENAL HOMEOBOX-1-ROLE IN GASTRIC ENDOCRINE PATTERNING", Mechanisms of development, 60(2), 1996, pp. 175-184

Abstract

The gastrointestinal tract is subdivided into regions with different roles in digestion and absorption. How this patterning is established is unknown. We now report that the pancreatic-duodenal homeobox 1 gene(pdx1) is also expressed in cells of the distal stomach. Positive cells include subpopulations of the three main endocrine (gastrin, somatostatin and serotonin) cell types of this region. Pdx1 deficient mice were virtually devoid of gastrin cells, had normal numbers of somatostatin cells and increased numbers of serotonin cells. Pdx1 is thus important for development of the gastrin cells of the antropyloric mucosa of the stomach and probably acts by controlling the fate of gastrin/serotonin precursor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:16:47