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Titolo:
THE STIMULATORY EFFECT OF CLONIDINE THROUGH IMIDAZOLINE RECEPTORS ON LOCUS-COERULEUS NORADRENERGIC NEURONS IS MEDIATED BY EXCITATORY AMINO-ACIDS AND MODULATED BY SEROTONIN
Autore:
RUIZORTEGA JA; UGEDO L; PINEDA J; GARCIASEVILLA JA;
Indirizzi:
UNIV PAIS VASCO,DEPT FARMACOL E-48940 LEIOA SPAIN UNIV PAIS VASCO,DEPT FARMACOL E-48940 LEIOA SPAIN UNIV ILLES BALEARS,DEPT BIOL FONSMENTAL & CIENCIES SALUT E-07071 PALMA DE MALLORCA SPAIN
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 2, volume: 352, anno: 1995,
pagine: 121 - 126
SICI:
0028-1298(1995)352:2<121:TSEOCT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; NUCLEUS PARAGIGANTOCELLULARIS; SENSORY RESPONSIVENESS; PREFERRING RECEPTORS; DORSAL RAPHE; ACTIVATION; INHIBITION; AGONISTS; BINDING; NEUROTRANSMISSION;
Keywords:
CLONIDINE; KYNURENIC ACID; RESERPINE; ALPHA-METHYL-P-TYROSINE; P-CHLORO-PHENYLALANINE; I-IMIDAZOLINE RECEPTORS; LOCUS COERULEUS NORADRENERGIC NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Ruizortega et al., "THE STIMULATORY EFFECT OF CLONIDINE THROUGH IMIDAZOLINE RECEPTORS ON LOCUS-COERULEUS NORADRENERGIC NEURONS IS MEDIATED BY EXCITATORY AMINO-ACIDS AND MODULATED BY SEROTONIN", Naunyn-Schmiedeberg's archives of pharmacology, 352(2), 1995, pp. 121-126

Abstract

Clonidine and other imidazoline/oxazoline drugs, such as cirazoline and rilmenidine, have been shown to stimulate the activity of noradrenergic neurones in the locus coeruleus (NA-LC) by an alpha(2)-adrenoceptor-independent mechanism through the activation of I-imidazoline receptors. The endogenous modulation of the stimulatory effect of clonidineon NA-LC neurones was further investigated after inactivation of alpha(2)-adrenoceptors with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline(EEDQ). In EEDQ-pretreated rats (6 mg/kg, i.p., 6 h), clonidine caused and dose-dependent (320-5120 mu g/kg, i.v.) in the firing rate of NA-LC neurones (ED(50) = 809 mu g/kg, E(max) = 90%). The stimulatory effect of clonidine on NA-LC neurones was completely blocked by pretreatment of rats with the excitatory amino acid receptor antagonist kynurenic acid (1-3 mu mol in 10-30 mu l, i.c.v., 2-5 min before clonidine). In contrast, the stimulatory effect of clonidine on NA-LC neurones waspotentiated by pretreatment with reserpine (5 mg/kg, s.c., 18 h) (E(max) increased by 63%). Pretreatment with alpha-methyl-p-tyrosine (250 mg/kg, i.p., 24 h) did not alter the stimulatory effect of clonidine, but pretreatment with p-chloro-phenylalanine (400 mg/kg, i.p., 24 h) markedly enhanced the stimulatory effect of clonidine on NA-LC neurones(E(max) increased by 139%). The present results indicate that the imidazoline receptor-mediated stimulatory effect of clonidine on NA-LC neurones is an indirect effect dependent on an excitatory amino acid pathway and modulated by an inhibitory serotonin mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 03:48:11