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Titolo:
GRANULOCYTE-COLONY-STIMULATING FACTOR MOBILIZES PRIMITIVE HEMATOPOIETIC STEM-CELLS IN NORMAL INDIVIDUALS
Autore:
FUJISAKI T; OTSUKA T; HARADA M; OHNO Y; NIHO Y;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 1,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812 JAPAN KYUSHU UNIV,CTR CANC,HIGASHI KU FUKUOKA 812 JAPAN
Titolo Testata:
Bone marrow transplantation
fascicolo: 1, volume: 16, anno: 1995,
pagine: 57 - 62
SICI:
0268-3369(1995)16:1<57:GFMPH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD; PROGENITOR CELLS; ALLOGENEIC TRANSPLANTATION; G-CSF; MARROW; INVITRO; PROLIFERATION; CHEMOTHERAPY;
Keywords:
GRANULOCYTE COLONY-STIMULATING FACTOR (G-CSF); NORMAL INDIVIDUALS; LONG-TERM CULTURE INITIATING CELLS (LTC-IC);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
T. Fujisaki et al., "GRANULOCYTE-COLONY-STIMULATING FACTOR MOBILIZES PRIMITIVE HEMATOPOIETIC STEM-CELLS IN NORMAL INDIVIDUALS", Bone marrow transplantation, 16(1), 1995, pp. 57-62

Abstract

We studied the hematopoietic activity of peripheral blood stem cells (PBSC) mobilized by recombinant human granulocyte colony-stimulating factor (G-CSF) using semisolid and long-term culture systems (LTC) in 5normal individuals, Following 2 or 3 daily subcutaneous injections ofG-CSF (filgrastim; 1.5 mu g/kg), not only committed progenitors including CFU-GM, BFU-E, and CFU-Mix, but also long-term culture initiatingcells (LTC-IC) were increased in the peripheral blood, When the cellsderived from CFU-GM, BFU-E and CFU-Mix colonies were replated for secondary colony formation, a minor fraction of CFU-GM and CFU-Mix colonies formed after 3 days of G-CSF stimulation irt vivo could produce secondary colonies, Moreover, the replating capacity of primary colonies from 5-week-old LTC initiated after 3 days of G-CSF stimulation was increased compared to that from 5-week-old LTC initiated in a 'steady-state', These observations indicate that G-CSF can mobilize very primitive progenitors (LTC-IC) along with committed progenitors into the circulation and suggest that some of these G-CSF-mobilized progenitors mayretain self-renewal capacity.

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Documento generato il 18/09/20 alle ore 11:08:35