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Titolo:
EVALUATION OF AFRICAN MEDICINAL-PLANTS FOR THEIR IN-VITRO TRYPANOCIDAL ACTIVITY
Autore:
FREIBURGHAUS F; KAMINSKY R; NKUNYA MHH; BRUN R;
Indirizzi:
SWISS TROP INST CH-4002 BASEL SWITZERLAND UNIV DAR ES SALAAM,DEPT CHEM DAR ES SALAAM TANZANIA
Titolo Testata:
Journal of ethnopharmacology
fascicolo: 1, volume: 55, anno: 1996,
pagine: 1 - 11
SICI:
0378-8741(1996)55:1<1:EOAMFT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPANOSOMA-BRUCEI-BRUCEI; TRADITIONAL MEDICINE; ANNONA-SENEGALENSIS; PHYSALIN-F; INVENTORY; SOMALIA; EQUIPERDUM; EXTRACT; THERAPY; EVANSI;
Keywords:
MEDICINAL PLANTS; SLEEPING SICKNESS; TRYPANOSOMA BRUCEI RHODESIENSE; ANTITRYPANOSOMAL ACTIVITY; IN VITRO; AFRICA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
F. Freiburghaus et al., "EVALUATION OF AFRICAN MEDICINAL-PLANTS FOR THEIR IN-VITRO TRYPANOCIDAL ACTIVITY", Journal of ethnopharmacology, 55(1), 1996, pp. 1-11

Abstract

Petroleum ether, dichloromethane, methanol and water extracts from 24plants, belonging to 19 families, which are reported in the literature as traditional remedies for sleeping sickness (human African trypanosomiasis) were screened for in vitro activity against Trypanosoma brucei rhodesiense, as well as for cytotoxicity for a human fibroblast cell-line (WI-38). The trypanocidal activity of the natural compounds berberine and harmane, both documented as being trypanocidal, was also evaluated. Promising trypanocidal activity with IC50 values below 10 mu g/ml was found in 32 extracts of 13 plant species. The most active extracts with IC50 values below 1 mu g/ml were derived from Annona senegalensis, Bussea occidentalis and Physalis angulata. The plant extracts showed a modest selectivity index, in contrast to commercially available trypanocides which have a more distinct selective toxicity against trypanosomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 09:23:14