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Titolo:
OPEN TRIAL OF LAMOTRIGINE IN THE TREATMENT OF SELF-INJURIOUS-BEHAVIORIN AN ADOLESCENT WITH PROFOUND MENTAL-RETARDATION
Autore:
DAVANZO PA; KING BH;
Indirizzi:
UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT,SCH MED,DIV CHILD & ADOLESCENT PSYCHIAT,ROOM C8-849 LOS ANGELES CA 90024
Titolo Testata:
Journal of child and adolescent psychopharmacology
fascicolo: 4, volume: 6, anno: 1996,
pagine: 273 - 279
SICI:
1044-5463(1996)6:4<273:OTOLIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOLOGICAL EVALUATION; DOPAMINE DEFICIENCY; BITING BEHAVIOR; RATS; EPILEPSY; ACID; MUTILATION; MECHANISMS; RECEPTORS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Davanzo e B.H. King, "OPEN TRIAL OF LAMOTRIGINE IN THE TREATMENT OF SELF-INJURIOUS-BEHAVIORIN AN ADOLESCENT WITH PROFOUND MENTAL-RETARDATION", Journal of child and adolescent psychopharmacology, 6(4), 1996, pp. 273-279

Abstract

This single case reports an open trial of lamotrigine in the treatment of self-injurious behavior (SIE) and epilepsy in an IS-year-old female diagnosed with generalized seizure disorder, stereotypic movement disorder, and compulsive SIE in the context of profound mental retardation, Animal models of SIB suggest that the glutamate neurotransmitter systems, involved in the generation of epileptic seizures, may also have a role in the pathophysiology of SIE. Data suggesting that lamotrigine may decrease glutamate release encouraged an empirical trial of lamotrigine for treatment of SIE. After 4 weeks of treatment of lamotrigine 200 mg daily, decreases in agitation and fearfulness were clinically observed, along with a 50% reduction in the frequency of SIB as measured by standardized scales, Good seizure control was maintained throughout the trial, No significant adverse effects were observed, Positive effects persisted at I-year follow-up, Symptoms of stereotypic movement disorder appeared unchanged, Because these findings are preliminary, no clinical recommendations for the treatment of SIE with lamotrigine can be made until controlled studies have been completed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:08:35