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Titolo:
MICROWAVE-INDUCED LETHAL HEAT-STRESS - EFFECTS OF PHENTOLAMINE, PRAZOSIN AND METOPROLOL
Autore:
JAUCHEM JR; FREI MR; CHANG KS; BERGER RE;
Indirizzi:
ARMSTRONG LAB,OCCUPAT & ENVIRONM HLTH DIRECTORATE,DIV RADIOFREQUENCY RADIAT,BLDG 1184 BROOKS AFB TX 78235 TRINITY UNIV,DEPT BIOL SAN ANTONIO TX 78212 OPERAT TECHNOL CORP SAN ANTONIO TX 00000
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 4, volume: 17, anno: 1995,
pagine: 241 - 248
SICI:
0379-0355(1995)17:4<241:MLH-EO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOFREQUENCY RADIATION; BODY-TEMPERATURE; SEROTONERGIC AGENTS; THERMAL RESPONSES; BLOOD-VOLUME; HYPERTHERMIA; DRUGS; RATS; IRRADIATION; ANTAGONISTS;
Keywords:
BODY TEMPERATURE; MICROWAVES; THERMOREGULATION; PHENTOLAMINE; PRAZOSIN; METOPROLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Jauchem et al., "MICROWAVE-INDUCED LETHAL HEAT-STRESS - EFFECTS OF PHENTOLAMINE, PRAZOSIN AND METOPROLOL", Methods and findings in experimental and clinical pharmacology, 17(4), 1995, pp. 241-248

Abstract

Previous studies have shown that adrenergic antagonists can alter physiological responses to microwave-induced hearing. in the present experiments, 33 ketamine-anesthetized Sprague-Dawley rats were exposed to 2450-MHz microwaves at an average power density of 60 mW/sq cm (whole-body average specific absorption rate of approximately 14 W/kg) until death occurred. The effects of intra-arterial injections of the nonselective alpha-adrenoceptor antagonist phentolamine (10 mg/kg body weight), the alpha(1)-adrenoceptor antagonist prazosin (5 mg/kg), and the beta(1)-adrenoceptor antagonist metoprolol (2 mg/kg) on physiological responses (including changes in body temperature, heart rate, blood pressure, and respiratory rate) were examined. A group of saline-injectedanimals was included for comparison. There were no significant differences in lethal temperatures, survival times, or rates of temperature change among the different groups. In all groups, heart rate increasedcontinuously during exposure; mean arterial blood pressure increased until colonic temperature reached 41-41.5 degrees C, and then decreased. These heart rate and blood pressure changes were similar to those that occur during environmental heat stress. Despite differences in absolute values of heart heart rate and mean arterial blood pressure among groups, there were no significant differences in changes from baseline levels among groups. From these results, taken together with previous findings in our laboratory, it may be hypothesized that selective alpha(1) blockade (without concurrent alpha(2) blockade) and beta(2) blockade (with or without concurrent beta(1) blockade) are effective in altering physiological responses to microwave exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 13:56:46