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Titolo:
THE LIM-HOMEODOMAIN PROTEIN ISL-1 SEGREGATES WITH SOMATOSTATIN BUT NOT WITH GASTRIN EXPRESSION DURING DIFFERENTIATION OF SOMATOSTATIN GASTRIN PRECURSOR CELLS
Autore:
LARSSON LI; TINGSTEDT JE; MADSEN ID; SERUP P; HOUGAARD DM;
Indirizzi:
STATENS SERUM INST,DEPT MOLEC CELL BIOL,DIV BIOTECHNOL,ARTILLERIVEJ 5,BLDG 81 DK-2300 COPENHAGEN S DENMARK HAGEDORN RES INST DK-2820 GENTOFTE DENMARK
Titolo Testata:
Endocrine
fascicolo: 7, volume: 3, anno: 1995,
pagine: 519 - 524
SICI:
1355-008X(1995)3:7<519:TLPISW>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENT-BINDING-PROTEIN; PANCREATIC-ISLET CELLS; PERFUSED RAT STOMACH; RESPONSE ELEMENT; ENDOCRINE-CELLS; ANTRAL GASTRIN; MESSENGER-RNA; DEOXYRIBONUCLEIC-ACID; INSITU HYBRIDIZATION; GENE-EXPRESSION;
Keywords:
SOMATOSTATIN; GASTRIN; COEXPRESSION; ISL-1; HOMEOBOX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
L.I. Larsson et al., "THE LIM-HOMEODOMAIN PROTEIN ISL-1 SEGREGATES WITH SOMATOSTATIN BUT NOT WITH GASTRIN EXPRESSION DURING DIFFERENTIATION OF SOMATOSTATIN GASTRIN PRECURSOR CELLS", Endocrine, 3(7), 1995, pp. 519-524

Abstract

The gastric epithelium is renewed from stem cells in the isthmus of the gastric glands. We describe that the two neuroendocrine peptides gastrin and somatostatin are coexpressed by isthmic stem cells. Bromodeoxyuridine labeling indicates that the coexpressing cells divide and differentiate into gastrin and somatostatin cells, which remain in paracrine contact during most of their migration down into the gland. The coexpressing cells display nuclear immunoreactivity for the transcription factors Isl-1 and CREB, which have been implicated in somatostatin gene expression. Differentiated gastrin cells lack Isl-1 reactivity and show variable staining for CREB while differentiated somatostatin cells display 1sl-1 and CREB reactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:21:41