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Titolo:
LOWER AIRWAYS INFLAMMATORY RESPONSE DURING RHINOVIRUS COLDS
Autore:
BARDIN PG; FRAENKEL DJ; SANDERSON G; LAMPE F; HOLGATE ST;
Indirizzi:
UNIV STELLENBOSCH,POB 19063 TYGERBERG 7505 SOUTH AFRICA SOUTHAMPTON GEN HOSP SOUTHAMPTON HANTS ENGLAND
Titolo Testata:
International archives of allergy and immunology
fascicolo: 1-3, volume: 107, anno: 1995,
pagine: 127 - 129
SICI:
1018-2438(1995)107:1-3<127:LAIRDR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASTHMA;
Keywords:
RHINOVIRUS; COMMON COLD; ASTHMA; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
P.G. Bardin et al., "LOWER AIRWAYS INFLAMMATORY RESPONSE DURING RHINOVIRUS COLDS", International archives of allergy and immunology, 107(1-3), 1995, pp. 127-129

Abstract

Human rhinovirus (HRV) causes the majority of common colds and possibly also asthma exacerbations. Mechanisms linking viruses to changes inairway reactivity are not defined and we hypothesized that changes inendobronchial cell populations may be implicated. Bronchial mucosal biopsies taken before, during and after experimental infections with HRV serotype 16 were examined and histamine reactivity was measured in 17 adult volunteers (6 atopic asthmatics). Biopsies were examined for mast cells, eosinophils, lymphocytes and neutrophils by immunohistochemical techniques. Increases in histamine responsiveness (PC20) were found (p = 0.048), accompanied by an increase in submucosal lymphocytes (p = 0.05). There was a significant increase in epithelial eosinophils with the cold (p = 0.042), and in asthmatics this appeared to persist into convalescence. Rhinoviral common colds are associated with a bronchial mucosal lymphocytic and eosinophilic infiltrate that may be related to changes in airway responsiveness and asthma exacerbations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 08:35:03