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Titolo:
DETECTION OF 1-PHENYL-N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE IN HUMAN BRAIN BY GAS CHROMATOGRAPHY-TANDEM MASS-SPECTROMETRY
Autore:
KAJITA M; NIWA T; FUJISAKI M; UEKI M; NIIMURA K; SATO M; EGAMI K; NAOI M; YOSHIDA M; NAGATSU T;
Indirizzi:
NAGOYA UNIV,BRANCH HOSP,HIGASHI KU,DAIKO MINAMI NAGOYA 461 AICHI JAPAN NAGOYA UNIV,BRANCH HOSP,HIGASHI KU NAGOYA 461 AICHI JAPAN MITSUBISHI YUKA BIOCLIN LABS TOKYO 174 JAPAN KUREHA CHEM IND,BIOMED RES LABS TOKYO 169 JAPAN NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU NAGOYA AICHI 466 JAPAN JICHI MED SCH,DEPT NEUROL MINAMI KAWACHI TOCHIGI 32904 JAPAN FUJITA HLTH UNIV,SCH MED,INST COMPREHENS MED SCI,DEPT MOLEC GENET 2 TOYOAKE AICHI 47011 JAPAN
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 2, volume: 669, anno: 1995,
pagine: 345 - 351
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-METHYLISOQUINOLINIUM ION; ENDOGENOUS SUBSTANCE; INVIVO MICRODIALYSIS; PARKINSONS-DISEASE; TETRAHYDROISOQUINOLINE; N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE; 1,2,3,4-TETRAHYDROISOQUINOLINE; METHYLATION; PRECURSOR; PRIMATES;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Kajita et al., "DETECTION OF 1-PHENYL-N-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND 1-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE IN HUMAN BRAIN BY GAS CHROMATOGRAPHY-TANDEM MASS-SPECTROMETRY", Journal of chromatography B. Biomedical applications, 669(2), 1995, pp. 345-351

Abstract

1-Phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline were detected for the first time in parkinsonian human brain using gas chromatography-tandem mass spectrometry (GC-MS-MS). Since these compounds are structural analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that produces parkinsonism in humans, they might be candidates for endogenous MPTP-like neurotoxins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 13:58:52