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Titolo:
CORONARY HEART-DISEASE PREVALENCE AND ITS RELATION TO RISK-FACTORS INAMERICAN-INDIANS - THE STRONG HEART-STUDY
Autore:
HOWARD BV; LEE ET; COWAN LD; FABSITZ RR; HOWARD WJ; OOPIK AJ; ROBBINS DC; SAVAGE PJ; YEH JL; WELTY TK;
Indirizzi:
MEDLANT RES INST,108 IRVING ST NW WASHINGTON DC 20010 UNIV OKLAHOMA,HLTH SCI CTR,CTR EPIDEMIOL RES OKLAHOMA CITY OK 73190 UNIV OKLAHOMA,DEPT BIOSTAT & EPIDEMIOL OKLAHOMA CITY OK 73190 NHLBI BETHESDA MD 20892 FITZSIMONS ARMY MED CTR DENVER CO 00000 ABERDEEN AREA INDIAN HLTH SERV RAPID CITY SD 00000
Titolo Testata:
American journal of epidemiology
fascicolo: 3, volume: 142, anno: 1995,
pagine: 254 - 268
SICI:
0002-9262(1995)142:3<254:CHPAIR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; PIMA-INDIANS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; GLUCOSE-TOLERANCE; ALASKA NATIVES; BLOOD-PRESSURE; INSULIN; MORTALITY; POPULATION;
Keywords:
CORONARY DISEASE; DIABETES MELLITUS; HYPERTENSION; INDIANS, NORTH AMERICAN; INSULIN; LIPOPROTEINS; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
B.V. Howard et al., "CORONARY HEART-DISEASE PREVALENCE AND ITS RELATION TO RISK-FACTORS INAMERICAN-INDIANS - THE STRONG HEART-STUDY", American journal of epidemiology, 142(3), 1995, pp. 254-268

Abstract

Although coronary heart disease (CHD) is currently the leading cause of death among American Indians, information on the prevalence of CHD and its association with known cardiovascular risk factors is limited. The Strong Heart Study was initiated in 1988 to quantify cardiovascular disease and its risk factors among three geographically diverse groups of American Indians. Members of 13 Indian communities in Arizona, Oklahoma, and South and North Dakota between 45 and 74 years of age underwent a physical examination that included medical history; an electrocardiogram; anthropometric and blood pressure measurements; an oral glucose tolerance test; and measurements of fasting plasma lipoproteins, fibrinogen, insulin, hemoglobin A1(c), and urinary albumin. Prevalence rates of definite myocardial infarction and definite CHD were higher in men than in women at all three centers (p < 0.0001) and higher in those with diabetes mellitus (p = 0.002 in men and p = 0.0003 in women). Diabetes was associated with relatively higher prevalence rates of myocardial infarction (diabetic: nondiabetic prevalence ratio = 3.8 vs. 1.9) and CHD (prevalence ratio = 4.6 vs. 1.8) in women than in men. Prevalence rates of heart disease were lowest in the communities in Arizona; prevalence rates were similar in Oklahoma and South Dakota/North Dakota and were two- to threefold higher than those in Arizona. Bylogistic regression, prevalent CHD among American Indians was significantly and independently related to age, diabetes, hypertension, albuminuria, percentage of body fat, smoking, high concentrations of plasmainsulin, and low concentrations of high density lipoprotein cholesterol. In contrast to reports from other non-Indian populations, diabeteswas the strongest risk factor. The lower prevalence of CHD among Indians in Arizona is distinctive in view of their higher rates of diabetes, obesity, hypertension, and albuminuria, but it may be partly related to their low frequency of smoking and their low concentrations of total and low density lipoprotein cholesterol. These findings from the initial Strong Heart Study examination emphasize the importance of diabetes and its associated variables as risk factors for CHD in Native American populations.

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Documento generato il 01/12/20 alle ore 09:51:49