Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF A LOW-BIRTH-WEIGHT INFANT FORMULA CONTAINING HUMAN-MILK LEVELS OF DOCOSAHEXAENOIC AND ARACHIDONIC ACIDS
Autore:
KOLETZKO B; EDENHOFER S; LIPOWSKY G; REINHARDT D;
Indirizzi:
UNIV MUNICH,KINDERPOLIKLIN,PETTENKOFERSTR 8A D-80336 MUNICH GERMANY
Titolo Testata:
Journal of pediatric gastroenterology and nutrition
fascicolo: 2, volume: 21, anno: 1995,
pagine: 200 - 208
SICI:
0277-2116(1995)21:2<200:EOALIF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYUNSATURATED FATTY-ACIDS; BIRTH-WEIGHT INFANTS; FISH OIL SUPPLEMENTATION; MATURE HUMAN-MILK; PRETERM INFANTS; VITAMIN-E; VISUAL-ACUITY; BETA-CAROTENE; BREAST-MILK; PLASMA;
Keywords:
ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; NEONATAL NUTRITION; INFANT FEEDING; TRANS FATTY ACIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
B. Koletzko et al., "EFFECTS OF A LOW-BIRTH-WEIGHT INFANT FORMULA CONTAINING HUMAN-MILK LEVELS OF DOCOSAHEXAENOIC AND ARACHIDONIC ACIDS", Journal of pediatric gastroenterology and nutrition, 21(2), 1995, pp. 200-208

Abstract

Long-chain (LC) polyunsaturated fatty acids (PUFA) (LCP) are considered conditionally essential nutrients for low birth weight infants (LBWI). Therefore, enrichment of LBWI formulae with metabolites both linoleic (omega-6) and alpha-linolenic (omega-3) acids at levels typical for human milk has been recommended. However, previous feeding trials with LCP-enriched formulae evaluated only a dietary supplementation withomega-3 LCP from fish oils alone or with both omega-3 and omega-6 LCPat levels considerably lower than usual human milk contents. We studied the effects of an LBWI formula providing the major omega-3 and omega-6 LCP, docosahexaenoic and arachidonic acids, in amounts similar to those in average human milk. Twenty-seven LBWIs were enrolled in this study when they tolerated full enteral feeding (greater than or equal to 130 mi milk/kg/day). Infants either received their own mother's milk (n = 8, birthweight 1218 +/- 146 g, gestational age 30.2 +/- 1.5 weeks, mean +/- SD) fortified with protein and minerals (FM-85, Nestle Ag, Munchen, Germany; dosage 5 g/100 mi milk) or were randomly assigned to blinded batches of an LBWI formula (Prematil, Milupa AG, Friedrichsdorf, Germany) without LCP (n = 10, 1280 +/- 229 g, 31.1 +/- 3.1 weeks) or with LCP (n = 9, 1253 +/- 334 g, 30.4 +/- 3.3 wks.). During the study period of 21 days, the three feeding groups did not differ in growth and feeding tolerances as assessed by occurrence of gastric residuals, spitting, or abdominal distention; however, firms stools were noted more frequently in the two formula groups. Compared to infants fed human milk, those on formula without LCP showed significant depletion of plasma phospholipid arachidonic acid (reduced to 74% of levels found in infants fed human milk) and, even more marked, of docosahexaenoicacid (reduced to 64%) as well as total LCP (74%), within 3 weeks of full enteral feeding. In contrast, infants receiving the LCP-enriched formula achieved an LCP status equal to that of human milk-fed babies. Results indicate that LBWI absorb formula LCPs and incorporate them into endogenous phospholipids. There were no adverse effects of LCP enrichment on vitamin-E status. We conclude that the LCP enrichment of theformula used in this study was well tolerated, did not interfere withshort-term growth or vitamin-E status, and provided sufficient amounts of essential fatty acids to match the omega-3 and omega-6 LCP statusof infants fed human milk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:23:40