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Titolo:
GLUCOSE-UTILIZATION IN MORBIDLY OBESE SUBJECTS BEFORE AND AFTER WEIGHT-LOSS BY GASTRIC BYPASS OPERATION
Autore:
BURSTEIN R; EPSTEIN Y; CHARUZI I; SUESSHOLZ A; KARNIELI E; SHAPIRO Y;
Indirizzi:
CHAIM SHEBA MED CTR,HELLER INST MED RES IL-52621 TEL HASHOMER ISRAEL CHAIM SHEBA MED CTR,HELLER INST MED RES IL-52621 TEL HASHOMER ISRAEL SOROKA MED CTR,DEPT SURG C BEER SHEVA ISRAEL TECHNION ISRAEL INST TECHNOL,RAMBAM MED CTR,ENDOCRINE METAB UNIT HAIFA ISRAEL
Titolo Testata:
International journal of obesity
fascicolo: 8, volume: 19, anno: 1995,
pagine: 558 - 561
SICI:
0307-0565(1995)19:8<558:GIMOSB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-DEPENDENT DIABETICS; SKELETAL-MUSCLE; RESISTANT PATIENTS; TRANSPORTER; TOLERANCE; MELLITUS; NIDDM; GLUT4; SENSITIVITY; EXPRESSION;
Keywords:
INSULIN SENSITIVITY; RESPONSIVENESS; MORBID OBESITY; SURGICAL INTERVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Burstein et al., "GLUCOSE-UTILIZATION IN MORBIDLY OBESE SUBJECTS BEFORE AND AFTER WEIGHT-LOSS BY GASTRIC BYPASS OPERATION", International journal of obesity, 19(8), 1995, pp. 558-561

Abstract

OBJECTIVE: To investigate the effect of weight reduction induced by gastric bypass operation (GBO), on the peripheral resistance to insulinin extremely obese subjects. DESIGN: A three-stage euglycemic clamp was applied to assess the metabolic clearance rate of glucose (g-MCR) in lean controls and in obese subjects, prior to and 6-12 months post operation. SUBJECTS: Six obese subjects (four obese normoglycemics-ON and two obese non-insulin dependent diabetics-OD) before and after GBO and six healthy, lean controls (LC) were compared. MAIN OUTCOME MEASURES: Body mass index after GBO, metabolic clearance rate of glucose under increasing insulin concentrations. RESULTS: GBO resulted in a significant change in body mass index from a pre-operation value (mean +/- s.d.) of 45.0 +/- 8.5 to 30.4 +/- 5.9 kg m(-2) and remained significantly greater than controls (23.3 +/- 2.3 kg m(-2)). Glucose MCR increased from a mean baseline value of 3.0 +/- 1.6 to 6.7 +/- 3.9 ml kg(-1) min(-1) at post GBO (P) (P < 0.02), Similar effects were obtained under the two higher insulin concentration. CONCLUSIONS: GBO resulted in amassive reduction in BMI, that still remained above normal controls. This could explain the effect of weight reduction to decrease, but notcompletely reverse, peripheral resistance to insulin associated with obesity.

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Documento generato il 12/07/20 alle ore 12:15:31