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Titolo:
PLECKSTRIN HOMOLOGY DOMAINS - A FACT FILE
Autore:
SARASTE M; HYVONEN M;
Indirizzi:
EUROPEAN MOLEC BIOL LAB,POSTFACH 102209 D-69012 HEIDELBERG GERMANY
Titolo Testata:
Current opinion in structural biology
fascicolo: 3, volume: 5, anno: 1995,
pagine: 403 - 408
SICI:
0959-440X(1995)5:3<403:PHD-AF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE-C SUBSTRATE; SIGNALING PROTEINS; PH DOMAIN; PLATELETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Saraste e M. Hyvonen, "PLECKSTRIN HOMOLOGY DOMAINS - A FACT FILE", Current opinion in structural biology, 5(3), 1995, pp. 403-408

Abstract

Structures of three different pleckstrin homology domains have been determined within the past year. They have a common core consisting of a seven-stranded and strongly bent beta-sheet and a C-terminal alpha-helix that packs against the beta-sheet. Phosphatidylinositol 4,5-bisphosphate and related compounds specifically bind to pleckstrin homologydomains, suggesting that the domain may be involved in reversible anchorage to membranes or in recognition of a second messenger, such as inositol 1,4,5-trisphosphate, Pleckstrin homology domains have also been suggested to bind to the G(beta gamma) complex, but direct evidence for this is missing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:31:33