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Titolo:
STRUCTURE AND MAPPING OF THE HUMAN THYMOPOIETIN (TMPO) GENE AND RELATIONSHIP OF HUMAN TMPO-BETA TO RAT LAMIN-ASSOCIATED POLYPEPTIDE-2
Autore:
HARRIS CA; ANDRYUK PJ; CLINE SW; MATHEW S; SIEKIERKA JJ; GOLDSTEIN G;
Indirizzi:
RW JOHNSON PHARMACEUT RES INST,POB 300 RARITAN NJ 08869 IMMUNOBIOL RES INST ANNANDALE NJ 08801 MEM SLOAN KETTERING CANC CTR,CANC GENET LAB NEW YORK NY 10021
Titolo Testata:
Genomics
fascicolo: 2, volume: 28, anno: 1995,
pagine: 198 - 205
SICI:
0888-7543(1995)28:2<198:SAMOTH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-SEQUENCE; DOUBLE-BLIND; LONG ARM; TRANSCRIPTION; THYMOPENTIN; BINDING; CLONING; CHROMOSOME-12; EXPRESSION; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Harris et al., "STRUCTURE AND MAPPING OF THE HUMAN THYMOPOIETIN (TMPO) GENE AND RELATIONSHIP OF HUMAN TMPO-BETA TO RAT LAMIN-ASSOCIATED POLYPEPTIDE-2", Genomics, 28(2), 1995, pp. 198-205

Abstract

Thymopoietins (TMPOs, previously abbreviated TPs) alpha (75 kDa), beta (51 kDa), and gamma (39 kDa) are related nuclear proteins expressed in many or all tissues. TMPO alpha is present diffusely throughout thenucleus, while TMPOs beta and gamma are localized to the nuclear membrane. Here we report the cloning and analysis of a single TMPO gene encoding TMPOs alpha, beta, and gamma, which are produced by alternativemRNA splicing, as previously inferred from cDNA sequences. The eight exons of the TMPO gene are spread over similar to 35 kb. Exon 4, whichis spliced into TMPO alpha mRNA, contains sequences that encode a putative basic nuclear localization motif. Exon 8, which is spliced into TMPO beta and gamma mRNAs, encodes a hydrophobic putative membrane-spanning domain that is thought to target TMPOs beta and gamma to the nuclear membrane. TMPO beta appears to be the human homologue of the recently described rat protein LAPS (lamina-associated polypeptide 2), which is thought to play an important role in the regulation of nuclear architecture by binding lamin B1 and chromosomes in a manner regulated by phosphorylation during mitosis (K. Furukawa and L. Gerace, La Jolla, pers. comm., 22 Nov. 1994). The human TMPO gene maps to chromosome band 12q22. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:07:25