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Titolo:
ANTIBODY-PRODUCTION IN SYPHACIA-OBVELATA-INFECTED MICE
Autore:
SATO Y; OOI HK; NONAKA N; OKU Y; KAMIYA M;
Indirizzi:
HOKKAIDO UNIV,FAC VET MED,DEPT PARASITOL SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
The Journal of parasitology
fascicolo: 4, volume: 81, anno: 1995,
pagine: 559 - 562
SICI:
0022-3395(1995)81:4<559:AISM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
Y. Sato et al., "ANTIBODY-PRODUCTION IN SYPHACIA-OBVELATA-INFECTED MICE", The Journal of parasitology, 81(4), 1995, pp. 559-562

Abstract

Antibody response to Syphacia obvelata infection was observed in AKR/J mice by ELISA. Experimental infection with the pinworm eggs showed the presence of specific IgG against S. obvelata somatic antigens at 12days postinfection, and that it increased steadily thereafter. Sera of S. obvelata-infected mice showed cross-reactivity with somatic antigens of other Syphacia species such as S. mesocriceti and S. muris, butnot with Aspiculuris asiatica. Western blotting of S. obvelata antigen with sera of S. obvelata-infected mice showed a corresponding increase in the number of bands during the course of infection. Infected mice showed significantly higher antibody production to sheep red blood cells than the uninfected control mice. Thus, S. obvelata infection is shown to alter the humoral response to nonparasitic antigenic stimuli. These observations indicate that infection by helminths, which apparently do not produce clinical symptoms, might modulate the immune system of the host and, therefore, affect experimental results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 12:56:56