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Titolo:
TREATMENT OF ACUTE MYOCARDIAL-INFARCTION WITH STREPTOKINASE DOES NOT APPEAR TO MODULATE CIRCULATING NEUTROPHIL FUNCTION
Autore:
ADAMS SA; FROESE SP; GREEN BKW; COMMERFORD PJ; KISCH RE; SHEPHARD EG; ROBSON SC;
Indirizzi:
UNIV CAPE TOWN,DEPT MED,MRC,LIVER RES CTR CAPE TOWN 7925 SOUTH AFRICA UNIV CAPE TOWN,DEPT MED,MRC,LIVER RES CTR CAPE TOWN 7925 SOUTH AFRICA UNIV CAPE TOWN,CARDIAC CLIN CAPE TOWN 7925 SOUTH AFRICA GROOTE SCHUUR HOSP CAPE TOWN 7925 SOUTH AFRICA
Titolo Testata:
Clinical cardiology
fascicolo: 8, volume: 18, anno: 1995,
pagine: 459 - 463
SICI:
0160-9289(1995)18:8<459:TOAMWS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; REPERFUSION INJURY; ENDOTHELIAL-CELLS; MONOCLONAL-ANTIBODY; FIBRINOGEN; ADHERENCE; GLYCOPROTEIN; EXPRESSION; MECHANISM; SELECTINS;
Keywords:
MYOCARDIAL INFARCTION; STREPTOKINASE; NEUTROPHIL ADHESION; INTEGRIN; SELECTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Adams et al., "TREATMENT OF ACUTE MYOCARDIAL-INFARCTION WITH STREPTOKINASE DOES NOT APPEAR TO MODULATE CIRCULATING NEUTROPHIL FUNCTION", Clinical cardiology, 18(8), 1995, pp. 459-463

Abstract

The administration of thrombolytic therapy is the most common method of achieving patency of the occluded coronary artery in patients with acute myocardial infarction (AMI). However, thrombolytic agents and the byproducts of fibrinolysis have the potential to affect neutrophil activation and thus function, thereby augmenting myocardial damage further. This study assessed the effect of streptokinase administration onthe function of circulating neutrophils in patients with AMT. For this neutrophil adherence to human umbilical vein endothelial cells, homotypic neutrophil aggregation, and CD11b and L-selectin expression on the neutrophil membrane prior to and 1 h and 6 h after thrombolytic therapy was monitored. The study population included patients with AMI who received aspirin and streptokinase, and healthy laboratory workers who received aspirin only; all subjects acted as their own controls. Circulating fibrin degradation products and white cells were markedly raised following administration of streptokinase. No significant differences in neutrophil adherence to endothelium, homotypic neutrophil interactions, and CD11b or L-selectin expression were demonstrated betweenneutrophils, either pre-or post-thrombolytic therapy in the infarct group, or between neutrophils from the infarct group and from the control group. It was concluded that streptokinase produces an abrupt neutrophil leukocytosis together with a marked increase in circulating levels of fibrin degradation products. The assay systems used were unable to show significant sequential changes in circulating neutrophil adhesion and L-selectin or CD11b expression in patients with AMT following thrombolytic therapy or when these patients were compared with controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:24:49