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Titolo:
THYMOSIN FRACTION-5 DOES NOT INFLUENCE URINARY-TRACT CARCINOGENESIS BY PHENACETIN AND N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE IN NON SHI MICE/
Autore:
MURAI T; IWATA H; MORI S; HATO F; KIMURA S; KINOSHITA Y; WADA S; KISHIMOTO T; MAKINO S; OOHARA T; FUKUSHIMA S;
Indirizzi:
OSAKA CITY UNIV,SCH MED,DEPT PATHOL 1,ABENO KU,1-4-54 ASAHI MACHI OSAKA 545 JAPAN OSAKA CITY UNIV,SCH MED,DEPT PHYSIOL 2,ABENO KU OSAKA 545 JAPAN OSAKA CITY UNIV,SCH MED,DEPT UROL,ABENO KU OSAKA 545 JAPAN SHIONOGI & CO LTD,SHIONOGI RES LABS,ABURAHI LABS SHIGA 52034 JAPAN
Titolo Testata:
Oncology research
fascicolo: 3-4, volume: 7, anno: 1995,
pagine: 139 - 144
SICI:
0965-0407(1995)7:3-4<139:TFDNIU>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLADDER-TUMOR INDUCTION; RENAL PELVIC CARCINOMA; RATS; THYMOCYTES; REDUCTION; THYMUS; RESPONSIVENESS; LYMPHOCYTES; INVITRO; CANCERS;
Keywords:
THYMOSIN FRACTION 5; NON/SHI MOUSE; URINARY TRACT CARCINOGENESIS; N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE; PHENACETIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
T. Murai et al., "THYMOSIN FRACTION-5 DOES NOT INFLUENCE URINARY-TRACT CARCINOGENESIS BY PHENACETIN AND N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE IN NON SHI MICE/", Oncology research, 7(3-4), 1995, pp. 139-144

Abstract

The effect of thymosin fraction 5 (TF5) on the promotion and progression phases of urinary tract carcinogenesis induced by consecutive administration of phenacetin and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in NON/Shi mice was investigated. The study was carried out twice with a minor modification to the protocol in the second experiment. Fifty-seven male NON/Shi mice in experiment 1 and 100 mice in experiment 2 were each divided into four groups. Phenacetin was administered for 8 weeks in experiment 1 and 12 weeks in experiment 2, and subsequentlyBBN was given for 6 weeks in both cases, for total observation periods of 30 and 34 weeks, respectively. Sixty micrograms of TF5 per mouse was inoculated subcutaneously twice a week during (group 2) or after (group 3) BBN exposure, or both periods (group 4). Group 1 served as a control group without TF5 treatment. Histopathological examination revealed no effects on either induction of urinary tract carcinomas or distant metastasis from renal pelvic carcinomas in either experiment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:04:33