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Titolo:
CARCINOGENICITY OF POLICOSANOL IN MICE - AN 18-MONTH STUDY
Autore:
ALEMAN CL; PUIG MN; ELIAS EC; ORTEGA CH; GUERRA IR; FERREIRO RM; BRINIS F;
Indirizzi:
CTR NACL INVEST CIENT,CTR PROD NAT,AVE 25 & 158 ST,APDO 6880 HAVANA CUBA
Titolo Testata:
Food and chemical toxicology
fascicolo: 7, volume: 33, anno: 1995,
pagine: 573 - 578
SICI:
0278-6915(1995)33:7<573:COPIM->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS TUMORS; LONG-TERM; CHEMICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
C.L. Aleman et al., "CARCINOGENICITY OF POLICOSANOL IN MICE - AN 18-MONTH STUDY", Food and chemical toxicology, 33(7), 1995, pp. 573-578

Abstract

Policosanol (trade name Ateromixol) is a new cholesterol-lowering drug that has been isolated and purified from sugar cane wax. The effectsof policosanol (50-500 mg/kg) administered orally for 18 months to male and female Swiss mice were investigated. No differences in daily clinical observations, weight gain, food consumption and mortality (survival analysis) between groups were found. Histopathological study showed that the frequency of neoplastic (benign and malignant) lesions wassimilar in the control and policosanol-treated groups. The lesions observed were similar to the spontaneous lesions in Swiss mice reported in previous studies. As no drug-related increase in the occurrence of malignant or benign neoplasm was found, nor acceleration in tumour growth in any specific group observed, this study shows no evidence of policosanol-induced carcinogenicity in Swiss mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:27:30