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Titolo:
EFFECTS OF LONG-TERM OVARIECTOMY AND OVARIAN-STEROIDS ON SOMATOGENIC BINDING-SITES IN RAT-BRAIN AND LIVER
Autore:
MUSTAFA A; BOGDANOVIC N; NYBERG F; SULIMAN I; ISLAM A; ROOS P; WINBLAD B; ADEM A;
Indirizzi:
KAROLINSKA INST,HUDDINGE HOSP,DEPT GERIATR MED S-14186 HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE HOSP,DEPT GERIATR MED S-14186 HUDDINGE SWEDEN UNIV UPPSALA,DEPT PHARMACEUT BIOSCI,DIV BIOL RES DRUG DEPENDENCE UPPSALA SWEDEN UNIV UPPSALA,DEPT BIOCHEM UPPSALA SWEDEN KAROLINSKA INST,HUDDINGE HOSP,DEPT ORTHOPAED SURG S-14186 HUDDINGE SWEDEN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 194, anno: 1995,
pagine: 193 - 196
SICI:
0304-3940(1995)194:3<193:EOLOAO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; PITUITARY; GH; HYPOTHALAMUS; LOCALIZATION; RECEPTORS;
Keywords:
GROWTH HORMONE; LONG-TERM OVARIECTOMY; OVARIAN STEROIDS; RAT BRAIN; RECEPTOR AUTORADIOGRAPHY; SOMATOGENIC BINDING SITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A. Mustafa et al., "EFFECTS OF LONG-TERM OVARIECTOMY AND OVARIAN-STEROIDS ON SOMATOGENIC BINDING-SITES IN RAT-BRAIN AND LIVER", Neuroscience letters, 194(3), 1995, pp. 193-196

Abstract

The effects of long-term ovariectomy and replacement with ovarian steroids on the levels of brain and liver somatogenic binding sites as well as plasma and liver growth hormone (GH) were studied in sham-operated (Sham) and ovariectomized female rats receiving either, 17 beta-estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX). Long-term ovariectomy decreased the levels of somatogenic binding sites in the choroid plexus and liver as well as GH in plasma and liver. The levels of these sites in the choroid plexus were partially restored only by estradiol replacement. Moreover, exogenous estradiol but not progesterone restored the levels of plasma and liver GH as well as liver somatogenicbinding sites. Our results suggest that estrogens regulate the levelsof somatogenic binding sites in the liver and choroid plexus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:41:48