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Titolo:
ROLE OF ALPHA(1)-ADRENOCEPTERS AND ALPHA(2)-ADRENOCEPTORS OF THE LATERAL HYPOTHALAMIC AREA ON URINARY-EXCRETION CAUSED BY CENTRALLY ADMINISTERED ANGIOTENSIN-II
Autore:
SAAD WA; CAMARGO LAD; RENZI A; MENANI JV; SAAD WA;
Indirizzi:
PAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST BR-14801903ARARAQUARA SP BRAZIL
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 194, anno: 1995,
pagine: 169 - 172
SICI:
0304-3940(1995)194:3<169:ROAAAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL EXCRETION; WATER-INTAKE; RAT; SODIUM; CLONIDINE; DRINKING;
Keywords:
SODIUM; POTASSIUM; URINARY VOLUME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Saad et al., "ROLE OF ALPHA(1)-ADRENOCEPTERS AND ALPHA(2)-ADRENOCEPTORS OF THE LATERAL HYPOTHALAMIC AREA ON URINARY-EXCRETION CAUSED BY CENTRALLY ADMINISTERED ANGIOTENSIN-II", Neuroscience letters, 194(3), 1995, pp. 169-172

Abstract

To determine whether central alpha(1) and alpha(2)-adrenergic mechanisms are involved in urinary sodium and potassium excretion and urine volume induced by angiotensin II (ANGII), these renal parameters were measured in volume-expanded Holtzman rats with cannulas implanted into lateral ventricle (LV) and lateral hypothalamus (LH). The injection ofANGII into LV in rats with volume expansion reduced the sodium, potassium and urine excretion in comparison to the control injections of isotonic saline, whereas prazosin (alpha(1) antagonist) potentiated these effects. Clonidine (alpha(2) agonist) and yohimbine (alpha(2) antagonist) injected into LH previous to injection of ANGII into LV also abolished the inhibitory effect of ANGII. These results suggest that the discharge of central alpha-adrenergic receptors has dual inhibitory and excitatory effect on antinatriuretic, antikaliuretic and antidiuretic effect induced by central ANGII in volume-expanded rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:58:59