Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ROLE OF ACCESSORY CELLS IN CYTOKINE PRODUCTION BY T-CELLS IN CHRONIC B-CELL LYMPHOCYTIC-LEUKEMIA
Autore:
DECKER T; FLOHR T; TRAUTMANN P; AMAN MJ; HOLTER W; MAJDIC O; HUBER C; PESCHEL C;
Indirizzi:
UNIV MAINZ,SCH MED,DEPT INTERNAL MED 3,DIV HEMATOL,LANGENBECKSTR 1 D-55131 MAINZ GERMANY UNIV MAINZ,SCH MED,DEPT INTERNAL MED 3,DIV HEMATOL D-55131 MAINZ GERMANY UNIV VIENNA,INST IMMUNOL VIENNA AUSTRIA
Titolo Testata:
Blood
fascicolo: 3, volume: 86, anno: 1995,
pagine: 1115 - 1123
SICI:
0006-4971(1995)86:3<1115:ROACIC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; IFN-GAMMA; MONOCLONAL-ANTIBODIES; ERYTHROCYTE RECEPTOR; PROLIFERATION; INTERLEUKIN-4; ACTIVATION; INDUCTION; RESPONSES; IL-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
T. Decker et al., "ROLE OF ACCESSORY CELLS IN CYTOKINE PRODUCTION BY T-CELLS IN CHRONIC B-CELL LYMPHOCYTIC-LEUKEMIA", Blood, 86(3), 1995, pp. 1115-1123

Abstract

We investigated the production of cytokines by highly purified T helper cells from B-cell chronic lymphocytic leukemia (B-CLL) patients stimulated by different activation pathways, and we studied the influenceof various accessory cell populations on the pattern of the secretionof cytokines, including interleukin (IL)-2, IL-4, interferon-gamma (IFN-gamma), and IL-10. Neither a qualitative nor a quantitative difference in cytokine production and proliferative capacity was observed in CLL-derived purified T cells compared with normal individuals, when T cells were stimulated by different pathways, including CD3, CD2, and costimulation with CD28. Addition of autologous accessory cells (aAC), however, dramatically influenced the cytokine pattern of normal versusB-CLL-derived T cells. CLL cells as aAC caused a marked increase of IL-2, whereas IFN-gamma was only slightly induced and IL-4 was not influenced. In contrast, in normal individuals addition of aAC, which predominantly consisted of monocytes, resulted in a significant increase of IFN-gamma and a reduction of IL-4 secretion. IL-2 production was inhibited by higher concentrations of aAC. The increased stimulation of IL-2 production by CLL cells was not specific to the leukemic cell population, as purified B cells from normal individuals had the same effect. On the other hand, purified monocytes from CLL patients and controls both induced IFN-gamma production and inhibited IL-4 secretion. After antigen-specific stimulation with tetanus toroid, cytokine secretionwas influenced by the type of aAC in a similar pattern. We conclude that T helper cells derived from patients with B-CLL are intrinsically normal and that the predominance of B cells as accessory cells in CLL significantly alters the immune function of T helper cells in vitro. (C) 1995 by The American Society of Hematology.

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Documento generato il 24/09/20 alle ore 08:24:03