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Titolo:
MODULATION OF ACUTE GRAFT-VERSUS-HOST DISEASE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION BY TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) RELEASE IN THE COURSE OF PRETRANSPLANT CONDITIONING - ROLE OF CONDITIONING REGIMENS AND PROPHYLACTIC APPLICATION OF A MONOCLONAL-ANTIBODY NEUTRALIZING HUMAN TNF-ALPHA (MAK 195F)
Autore:
HOLLER E; KOLB HJ; MITTERMULLER J; KAUL M; LEDDEROSE G; DUELL T; SEEBER B; SCHLEUNING M; HINTERMEIERKNABE R; ERTL B; KEMPENI J; WILMANNS W;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,MED KLIN 3,MARCHIONINISTR 15 D-81377MUNICH GERMANY GSF MUNICH,HAMATOLOGIKUM,INST KLIN HAMATOL MUNICH GERMANY KNOLL AG,ONKOL IMMUNOL ABT W-6700 LUDWIGSHAFEN GERMANY
Titolo Testata:
Blood
fascicolo: 3, volume: 86, anno: 1995,
pagine: 890 - 899
SICI:
0006-4971(1995)86:3<890:MOAGDA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELOID-LEUKEMIA; PERIPHERAL-BLOOD; FACTOR CACHECTIN; SERUM LEVELS; PENTOXIFYLLINE; COMPLICATIONS; PREVENTION; TOXICITIES; RADIATION; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E. Holler et al., "MODULATION OF ACUTE GRAFT-VERSUS-HOST DISEASE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION BY TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) RELEASE IN THE COURSE OF PRETRANSPLANT CONDITIONING - ROLE OF CONDITIONING REGIMENS AND PROPHYLACTIC APPLICATION OF A MONOCLONAL-ANTIBODY NEUTRALIZING HUMAN TNF-ALPHA (MAK 195F)", Blood, 86(3), 1995, pp. 890-899

Abstract

Contribution of host-related cytokine release in the course of pretransplant conditioning to early tissue damage and induction of acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) has been shown in experimental models. We performed a clinical phase I/II trial applying a monoclonal antibody neutralizing humantumor necrosis alpha (TNF alpha) during pretransplant conditioning asadditional prophylaxis in high-risk patients admitted to allogeneic BMT; TNF alpha serum levels and clinical courses in 21 patients receiving anti-TNF alpha prophylaxis were compared with data from 22 historical controls. Absence of significant release of TNF alpha in the periodof busulphan (BUS) treatment, but significant induction of TNF alpha by total body irradiation (TBI) and cyclophosphamide (CY) conditioningwere correlated with significantly earlier onset of acute GVHD in patients receiving TBI/CY regimens as compared with BUS/CY-treated patients, Prophylactic application of monoclonal anti-TNF alpha seemed to postpone onset of acute GVHD from day 15 to day 25 (P < .05) after TBI/CY and from day 33 to day 53 after BUS/CY (P < .10) conditioning. Application of monoclonal anti-TNF alpha in low and intermediate doses was safe and not associated with an increased incidence of infectious or hematologic complications. Thus, our data provide indirect and direct evidence for involvement of conditioning-related cytokine release in induction of early acute GVHD in the clinical setting and support further investigation of this novel approach in randomized trials. (C) 1995 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:05:02